[{"data":1,"prerenderedAt":-1},["ShallowReactive",2],{"health-studies-list:{\"conditionNormalized\":\"zhejiang-university\",\"overallStatus\":[\"RECRUITING\",\"AVAILABLE\",\"NOT_YET_RECRUITING\"],\"orderBy\":\"LastUpdateSubmitDate:desc\",\"size\":25,\"offset\":0}":3,"health-study-condition:zhejiang-university":26},{"pageToken":4,"total":5,"offset":6,"count":5,"results":7},null,1,0,[8],{"id":9,"slug":10,"hasResults":11,"nctId":12,"briefTitle":13,"officialTitle":14,"acronym":4,"eligibilityCriteria":15,"healthyVolunteers":11,"sex":16,"minAge":17,"maxAge":4,"enrollmentInfo":18,"targetDuration":4,"studyType":21,"phases":22,"briefSummary":24,"conditions":25,"keywords":27,"overallStatus":31,"whyStopped":4,"lastUpdateSubmitDate":32,"lastUpdatePostDateStruct":33,"startDateStruct":36,"completionDateStruct":38,"leadSponsor":40,"locationsCount":5},"100622298","phase-3-the-impact-of-fexofenadine-hydrochloride-on-the-prognosis-of-patients-post-acute-myocardial-infarction-100622298",false,"NCT07381803","The Impact of Fexofenadine Hydrochloride on the Prognosis of Patients Post-Acute Myocardial Infarction","The Impact of Fexofenadine Hydrochloride on the Prognosis of Patients Post-Acute Myocardial Infarction: A Randomized Clinical Trial (FEND Ⅱ)","Inclusion Criteria:\n\n* Age ≥ 18 years old.\n* Able to verbally confirm understanding of the trial risks, benefits, and treatment options of fexofenadine hydrochloride therapy. He\u002Fshe or his\u002Fher legal representative must provide written informed consent prior to participating in the clinical trial.\n* Acute ST-segment elevation myocardial infarction (STEMI) occurring within 7 days, with diagnostic criteria including:\n\n  i) Typical clinical symptoms: such as severe crushing pain in the retrosternal or precordial area, usually lasting more than 10-20 minutes, which may radiate to the left upper arm, jaw, neck, back, or shoulders, etc.; ii) Elevated serum cardiac troponin (cTn): at least one measurement above the upper limit of normal (99th percentile of the reference upper limit); iii) ST-segment elevation: new ST-segment elevation at the J point in 2 adjacent leads.\n* Echocardiography indicating segmental wall motion abnormalities.\n\nExclusion Criteria:\n\n* Need for long-term use of fexofenadine hydrochloride or other H1 receptor inhibitors.\n* Previous coronary artery bypass grafting (CABG) surgery.\n* History of severe renal failure with estimated glomerular filtration rate (eGFR) \\\u003C 30 ml\u002Fmin.\n* History of severe liver dysfunction.\n* History of concurrent severe infection, hepatobiliary obstruction, or malignant tumor.\n* Expected life expectancy of less than 2 years due to non-cardiac diseases.\n* Currently receiving immunosuppressive therapy.\n* Pregnant, potentially pregnant, or lactating women.\n* Contraindication to the study drug or examinations.\n* Failure to provide written informed consent.\n* Presence of mechanical complications (ventricular septal defect, papillary muscle dysfunction, acute mitral regurgitation), refractory cardiogenic shock unresponsive to vasopressors, acute left heart failure or pulmonary edema, or malignant arrhythmias uncontrolled by antiarrhythmic drugs at enrollment.","ALL","18 Years",{"count":19,"type":20},2804,"ESTIMATED","INTERVENTIONAL",[23],"PHASE3","The goal of this study is o evaluate the prognostic effect of fexofenadine hydrochloride in patients with myocardial infarction",[26],"Zhejiang University",[28,29,30],"myocardial infarction","cardiac fibrosis","cardiac MRI","RECRUITING","2026-08-05",{"date":34,"type":35},"2026-08-07","ACTUAL",{"date":37,"type":35},"2025-01-27",{"date":39,"type":20},"2027-06",{"name":41,"class":42},"Second Affiliated Hospital, Zhejiang University, School of Medicine","OTHER"]