225 IU Versus 300 IU Starting FSH Dose in PPOS for Good-Prognosis Women

Trial statusNot yet recruiting
Trial phaseNot applicable
Trial typeInterventional
Biological sexFemale
Age18-34
SponsorVietnam Military Medical University

About this trial

This randomized controlled trial will compare two starting doses of follicle-stimulating hormone (FSH), 225 IU and 300 IU, during progestin-primed ovarian stimulation (PPOS) in women undergoing in vitro fertilization (IVF) who have a good reproductive prognosis. Participants will be randomly assigned to receive either 225 IU or 300 IU of FSH at the start of ovarian stimulation. The study will evaluate whether the starting FSH dose affects oocyte and embryo outcomes, with blastocyst formation as the primary outcome. Other outcomes will include oocyte morphology, fertilization, embryo development, and embryo quality. The findings may help determine an appropriate starting FSH dose for women with a good prognosis undergoing IVF using the PPOS protocol.

Eligibility criteria

Qualifiers

Female patient or oocyte donor aged <35 years.

Body mass index (BMI) between 18 and 25 kg/m².

Antral follicle count (AFC) ≥8 on ultrasound; and

AMH level between 1.5 and 4.5 ng/mL.

Disqualifiers

Polycystic ovary syndrome (PCOS) diagnosed according to the Rotterdam criteria, currently referred to as polyendocrine metabolic ovarian syndrome (PMOS).

Structural abnormalities of the ovaries.

Ovarian endometriosis.

Medical or gynecological conditions that may affect ovarian response to controlled ovarian stimulation.

Trial design

Treatments tested in this trial

  • Follitropin Alfa (Follitrope)

Treatment groups

380 Participants
are divided into 2 treatment groups