2D:4D Digit Ratio and Urinary Stone Disease
ConditionUrinary Stone
Trial statusNot yet recruiting
Trial phaseNot listed
Trial typeObservational
Biological sexAll
Age18+
SponsorEmrah Kızılay
About this trial
This prospective observational case-control study will investigate whether the 2D:4D digit ratio is associated with urinary stone disease. Adults undergoing non-contrast computed tomography at Malatya Training and Research Hospital will be classified as cases if kidney and/or ureteral stones are detected and as controls if no urinary stones are detected and there is no previous history of stone disease or stone surgery. The lengths of the second and fourth fingers of both hands will be measured using a digital caliper by two independent observers who are blinded to the participant group. The study will also examine whether the 2D:4D ratio is associated with recurrent stone disease, stone burden, and bilateral or multiple stones.
Eligibility criteria
This trial does not accept healthy volunteersQualifiers
Age 18 years or older
Provision of written informed consent
Undergoing non-contrast computed tomography at Malatya Training and Research Hospital during the study period
For cases: presence of at least one kidney and/or ureteral stone on non-contrast computed tomography
Disqualifiers
Congenital deformity of the hands or fingers
History of hand or finger trauma, fracture, surgery, or amputation that may affect digit length measurement
Severe hand deformity, contracture, or advanced joint disease preventing reliable measurement
Incomplete, inadequate, or technically unreliable 2D:4D measurements
Trial population
The study population will consist of consecutive adults undergoing non-contrast computed tomography at Malatya Training and Research Hospital during the study period. Participants with kidney and/or ureteral stones will constitute the case group. Participants without urinary stones on computed tomography and without a previous history of urinary stone disease or stone surgery will constitute the control group.
Trial design
Design model
Case-only
Time perspective
Cross-sectional
Treatments tested in this trial
Not listed
Trial groups
300 Participants
are grouped into 2 trial groupsGroup A: Urinary Stone Disease Group
Group B: Stone-Free Control Group
Trial outcomes
Primary outcomes
1
Mean Bilateral 2D:4D Digit Ratio by Urinary Stone Disease Status
The lengths of the second and fourth digits of both hands will be measured using a digital caliper by two independent observers blinded to group status. Right and left 2D:4D ratios will be calculated by dividing the length of the second digit by the length of the fourth digit. The mean bilateral 2D:4D ratio will be calculated as the average of the right and left ratios and compared between participants with computed tomography-confirmed kidney and/or ureteral stones and stone-free controls.
Time frame
At enrollment, during the single study assessmentSecondary outcomes
1
Mean Bilateral 2D:4D Digit Ratio by Recurrent Stone Disease Status
Among participants with computed tomography-confirmed kidney and/or ureteral stones, recurrent stone disease will be defined as at least one previous physician-diagnosed urinary stone episode, spontaneous stone passage, or stone-related surgical intervention before the current stone episode. The mean bilateral 2D:4D ratio will be compared between participants with recurrent stone disease and those experiencing their first documented stone episode.
Time frame
At enrollment, during the single study assessment2
Association Between Mean Bilateral 2D:4D Digit Ratio and Total Stone Burden
Among participants with computed tomography-confirmed kidney and/or ureteral stones, total stone burden will be calculated as the sum of the maximum diameters of all detected stones in millimeters on non-contrast computed tomography. The association between mean bilateral 2D:4D ratio and total stone burden will be evaluated.
Time frame
At enrollment, during the single study assessment3
Mean Bilateral 2D:4D Digit Ratio by Bilateral and/or Multiple Stone Presentation
Among participants with computed tomography-confirmed kidney and/or ureteral stones, bilateral stone disease will be defined as the presence of stones on both sides of the urinary tract, and multiple stone disease will be defined as the presence of two or more distinct stones. The mean bilateral 2D:4D ratio will be compared between participants with bilateral and/or multiple stones and those with a solitary unilateral stone.
Time frame
At enrollment, during the single study assessmentSponsors and contacts
Click on the lead sponsor to view all of their trials.
Emrah Kızılay
Lead sponsor
Malatya Governor Research Hospital
Sponsor institution
Source ClinicalTrials.gov
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