3D MRE-Based Evaluation of Meningioma Mechanical Properties and Histological Features

ConditionMeningioma

Trial statusRecruiting

Trial phaseNot applicable

Trial typeInterventional

Biological sexAll

Age18-80

SponsorShengjing Hospital

About this trial

This prospective single-center study aims to evaluate the feasibility and clinical utility of three-dimensional magnetic resonance elastography (3D MRE) in assessing tumor stiffness and adhesion in patients with meningioma undergoing surgical resection. By correlating preoperative MRE-derived stiffness and adhesion maps with intraoperative findings and histopathological features, the study seeks to determine whether MRE can serve as a noninvasive imaging biomarker for surgical planning, risk stratification, and prediction of tumor behavior.

Eligibility criteria

This trial accepts healthy volunteers

Qualifiers

All patients undergoing meningeoma resection surgery are eligible for inclusion in the study cohort.

Disqualifiers

Patients with metallic implants or foreign bodies in their bodies (pacemakers, artificial metallic heart valves, metal joints, metal implants, and those who can not remove dentures, insulin pumps, or contraceptive rings)

Pregnant women in the first trimester (within three months)

Patients with severe claustrophobia or anxiety

Patients with severe fever

Trial design

Design model

Single group

Treatments tested in this trial

Magnetic Resonance Elastography
Diagnostic test
Participants will undergo preoperative 3D MRE to quantify tumor stiffness and generate adhesion maps. MRE is performed as an adjunct to standard brain MRI, using 60 Hz vibration frequency and specialized elastogram processing software. The resulting stiffness and adhesion data are made available to the neurosurgical team for surgical planning.
Intraoperative Assessment and Recording
Procedure/Surgery
During surgical resection, the neurosurgical team will systematically assess and record tumor stiffness, adhesion to surrounding structures, vascularity, resection time, and technical difficulty using a standardized intraoperative scale. These intraoperative findings will be compared to preoperative MRE parameters to evaluate the diagnostic and predictive value of MRE.

Treatment groups

300 Participants

are divided into 1 treatment group

Group A: MRE-Guided Surgery GroupExperimental treatment 2 interventions

Trial outcomes

Primary outcomes

Agreement Between MRE Stiffness and Intraoperative Tumor Consistency

The primary outcome is the correlation between preoperative 3D MRE-derived shear stiffness values and intraoperative tumor consistency as assessed by the neurosurgeon using a standardized ordinal scale (1-5). Agreement will be evaluated using Spearman correlation and Bland-Altman analysis.

Time frame

Intraoperative (Day of Surgery)

Sponsors and contacts

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Shengjing Hospital

Lead sponsor

Source ClinicalTrials.gov

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