7.0T Magnetic Resonance Imaging Study for Hepatic Encephalopathy

ConditionsHepatic Encephalopathy (HE)MRI fMRI Research

Trial statusNot yet recruiting

Trial phaseNot listed

Trial typeObservational

Biological sexAll

Age18-89

SponsorChinese PLA General Hospital

About this trial

This clinical trial study aims to detect the imaging characteristics of patients with hepatic encephalopathy (HE) using 7-Tesla (7T) magnetic resonance imaging (MRI).

Eligibility criteria

This trial accepts healthy volunteers

Qualifiers

Patients with clinical suspected or diagnosed hepatic encephalopathy according to relevant guidelines.The patient's education level is above primary school level.

Regular follow-up.

Disqualifiers

Contraindications to MRI.

Patients with cerebrovascular disease, brain tumors, epilepsy, other neurodegenerative disease.

Trial population

Patients with hepatic encephalopathy

Trial design

Design model

Case-control

Time perspective

Prospective

Treatments tested in this trial

7.0T MRI-Scan
Other intervention
7.0T MRI-Scan

Treatment groups

200 Participants

are divided into 1 treatment group

Group A: 7.0T Research1 intervention

Trial outcomes

Primary outcomes

Functional connectivity and structural alterations between individuals with different subtypes of HE and healthy subjects.

Functional connectivity calculation is mainly based on the BOLD sequence, which is used to describe the degree of connectivity between different brain regions and reflect the functional activity of the brain. Gray matter (GM) morphological destruction, cortical thickness, and subcortical nuclear volume in patients with hepatic encephalopathy were analyzed based on structural magnetic resonance imaging（sMRI）.

Time frame

5 years

Secondary outcomes

Correlation between spectral features of clinical variables and spectral features of imaging.

The clinical variable spectrum characteristics were constructed using the patients' medical records and test data. The distribution characteristics of clinical psychological characteristics and imaging spectrum characteristics were compared using a multidimensional matrix, and gene-imaging association analysis was used to evaluate imaging changes.

Time frame

5 years

Sponsors and contacts

Click on the lead sponsor to view all of their trials.

Chinese PLA General Hospital

Lead sponsor

Source ClinicalTrials.gov

This trial is not recruiting at the moment. You can still explore other options: