This is a prospective observational study. The investigators plan to utilize this model as a tool for early classification and interrogate ANS function of transplant recipients.
Patients must be > 16 years of age;
Patients receiving HLA-haploidentical transplants;
Patients have to sign an informed consent form before the start of the research procedure.
Tandem transplantation or multiple transplantations;
Mental or other medical conditions that make the patients unable to comply with the research treatment and monitoring requirements;
Patients who are ineligible for the study due to other factors, or will bear great risk if participating in the study.
Adult patients receiving HLA-haploidentical transplants at the Institute of Hematology, Chinese Academy of Medical Sciences (IHCAMS)
Cohort
Prospective
Not listed
Result of heart rate response to standing test
Autonomic nervous system functional tests including heart rate response to standing will be performed within one month before the transplantation and during 17-25 days after the transplantation.
Result of piloerection test
Autonomic nervous system functional tests including piloerection will be performed within one month before the transplantation and during 17-25 days after the transplantation.
Number of participants with abnormal dynamic electrocardiography readings
Dynamic electrocardiography will be performed within one month before the transplantation and during 17-25 days after the transplantation.
Incidence of severe acute GvHD after transplantation within 100 days and incidences of acute GvHD (any grade) in various target organs.
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