A Cohort Study on the Efficacy of Bariatric Surgery for Rapidly Progressing Diabetic Nephropathy

ConditionsBariatric Surgeries Diabetic Nephropathy

Trial statusRecruiting

Trial phaseNot listed

Trial typeObservational

Biological sexAll

Age18-65

SponsorChina-Japan Friendship Hospital

About this trial

Establish a cohort of diabetic kidney disease(DKD) patients with intensive weight loss treatment to evaluate the impact of intensive weight loss treatment on the renal prognosis of DKD and construct a prediction model for the improvement of renal outcomes after weight loss.

Eligibility criteria

This trial does not accept healthy volunteers

Qualifiers

Age 18 to 65 years old;

BMI>25Kg/m2 or abdominal obesity (i.e. waist circumference>90cm for men and>85cm for women);

eGFR<30ml/min/1.73m2 or urinary microalbumin≥300mg/g, eGFR<60ml/min/1.73m2.

Disqualifiers

Patients who are taking glucocorticoids;

Combined with tumors; ③Combined with autoimmune diseases; ④Serum albumin<25g/L.

Trial population

Obese patients with DKD treated with intensive weight loss or traditional treatment

Trial design

Design model

Cohort

Time perspective

Other

Treatments tested in this trial

Bariatric surgery
Procedure/Surgery
Laparoscopic sleeve gastrectomy or laparoscopic gastric bypass based on β-cell function
Non-surgical therapy
Other intervention
Diet management，exercise，metformin，GLP-1 receptor agonists and other drugs which can lose weight.

Treatment groups

100 Participants

are divided into 2 treatment groups

Group A: Surgical group2 interventions

Group B: Non-surgical group1 intervention