This randomized clinical trial compares postoperative pain and MMP-9 levels after root canal treatment of necrotic teeth with apical periodontitis, using either single-visit or two-visit instrumentation. The primary outcome is pain intensity measured at multiple intervals using a Visual Analogue Scale. The secondary outcome is the periapical expression of MMP-9 assessed via ELISA. The trial aims to determine whether treatment timing impacts inflammation and healing.
Age between 18-40 years.
Males/Females.
Non-Vital pulps.
Negative response to cold pulp tester (ethyl chloride spray*).
Medically compromised patients having significant systemic disorders. (ASA III or IV).
Teeth with swelling or fistulous tract.
Teeth with acute or chronic periapical abscess.
Mobility Grade II or III.
Parallel
single visit instrumentation
Procedure/Surgeryroot canal instrumentation will be done on single visit treatment
multiple visit instrumentation
Procedure/Surgeryroot canal treatment will be done on two visits
Post instrumentation Pain
Pain will be measured At 6,12, 24, 48 and 72 hours post instrumentation by Modified Visual Analogue Scale (VAS)
MMP-9 level
measure expression of MMP-9 After access cavity (pre-instrumentation \& 1 week post-instrumentation
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Marwa Hisham Mohamed Salah Eldin
Lead sponsor
Cairo University
Sponsor institution
This trial is not recruiting at the moment. You can still explore other options:
