This multicenter cohort study is based on the National Brain Tumor Registry of China (NBTRC). It will compare patients who underwent surgery for Pituitary Neuroendocrine Tumors (PitNETs) detected through health screening versus those diagnosed via outpatient consultations. The study will evaluate differences between the two groups in surgical metrics, patient-centered outcomes, and healthcare utilization.
Patients with PitNETs who underwent surgical resection at Beijing Tiantan Hospital from September 1, 2011, to November 30, 2019, together with those recorded in the NBTRC who underwent surgery from December 1, 2019, to December 31, 2021.
The department (health screening or outpatient clinics) where the definitive diagnosis confirmed was missing or unclear
PitNETs was recurrent or synchronous brain tumors of any histology existed
Admission was via the emergency department
Maximum tumor diameter on preoperative MRI were unavailable
Patients with PitNETs who underwent surgical resection at Beijing Tiantan Hospital from September 1, 2011, to November 30, 2019, together with those recorded in the NBTRC who underwent surgery from December 1, 2019, to December 31, 2021.
Cohort
Retrospective
Not listed
Preoperative maximum tumor diameter
Maximum tumor diameter in millimeters, measured on preoperative Magnetic Resonance Imaging (MRI), defined as the largest dimension of the tumor.
Extent of resection
Gross total resection (GTR) versus non-GTR, assessed by intraoperative findings combined with MRI performed within 72 hours after surgery.
Preoperative symptom phenotype
Presence or absence of preoperative symptoms (including visual decline, headache, hyperpituitarism, hypopituitarism, diplopia, cerebrospinal fluid leak, nonspecific symptoms, and other symptoms) reported by the patient at hospital admission, reflecting symptoms experienced during the preoperative period.
Time interval from symptom onset to surgery
Time in months from the date of symptom onset to the date of surgery, calculated from patient-reported history documented in medical records.
Length of hospital stay
Number of days from admission to discharge, calculated from medical records.
Operation duration
Total time of surgery, measured from the start to the end of the procedure, extracted from surgical records.
Total hospitalization costs
Total inpatient expenses in Chinese Yuan (CNY) during the index admission, including all medical services, medications, imaging, laboratory tests, and surgical fees, extracted from hospital billing records.
Click on the lead sponsor to view all of their trials.
