Through observational studies, the long-term changes in liver function, metabolic state, immune response and other aspects of children after biliary tract reconstruction during their growth process were systematically explored. The risks of these long-term physiological changes on chronic diseases such as cardiovascular diseases, diabetic diseases and liver cirrhosis in adulthood, as well as their impacts on cognitive function, musculoskeletal health and other aspects were evaluated. How do early physiological changes affect a patient's long-term health? Are there any potential biomarkers that can predict future health outcomes? Based on the research results, preventive and intervention measures that are helpful in reducing the risk of long-term complications are proposed.
Healthy children matched by age and gender were selected as the control group
Combined with other serious diseases (such as cancer, autoimmune diseases), having obvious liver function abnormalities before surgery or being undergoing other major treatments.
Children who were diagnosed with biliary atresia or choledochal cyst after birth and underwent biliary reconstruction surgery were selected. According to the year Stratified by factors such as age, gender and operation time to ensure the representativeness of the samples.
Cohort
Prospective
Not listed
Targeted metabolic component detection of feces
Metabolite concentration in feces measured by targeted metabolomics
Detection of targeted metabolic components in plasma
Metabolite concentration in plasma measured by targeted metabolomics
Fecal metagenomic sequencing
Gut microbial composition and functional genes assessed by fecal metagenomic sequencing
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