About this trial
Chronic right ventricular pacing has a deleterious effect on left ventricular (LV) function, namely pacing-induced cardiomyopathy (PICM). Several parametes make difference of effect on the occurrence of PICM and its subsequent clinical outcomes. In particular, recognition of a major determinant focused on the ECG or echocardiographic parameters including strain or genetic factor for occurrence of PICM may lead to better identification of patients at high risk. Investigators prospectively enroll a participant with documented high risk of PICM and clinically follow-up to idenify clinical impact of PICM (PICM syndrome) over a long period of time.
Eligibility criteria
This trial does not accept healthy volunteersQualifiers
Willng to participate in the study and able to sign informed consent
Undertaken ECG and echocardiogram including strain before and after device implantation
Disqualifiers
Less than 18 years of age
Being pregnant or plan to become pregnant
Advanced heart failure waiting in heart transplantation
Have a life expectancy of less than 1 year
Trial population
The study will enroll at least 1000 device patients from multi-centers in order to identify and assess a determinant of PICM and its clinical outcomes (PICM syndrome)
Trial design
Cohort
Prospective
Treatments tested in this trial
Not listed
Trial groups
Trial outcomes
Primary outcomes
Heart failure diagnosis and treatment
Occurrence of heart failure symptom, diagnosis and treatment
Secondary outcomes
Atrial and Ventricular arrhythmia diagnosis, heart failure admisssion and all-caused mortality
Occurrence of atrial, ventricular arrhythmia, hear failure admission and all-cause mortality
Sponsors and contacts
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Eulji University Hospital
Lead sponsor
Chung-Ang University Hosptial, Chung-Ang University College of Medicine
Sponsor institution
Chungnam National University Hospital
Collaborator
Chungbuk National University Hospital
Collaborator
Dankook University
Collaborator
Chung-Ang University Hosptial, Chung-Ang University College of Medicine
Collaborator