A Multicenter Prospective Clinical Cohort Study on the Pathogen Spectrum of HIV/AIDS Complicated With Infection
Trial statusNot yet recruiting
Trial phaseNot listed
Trial typeObservational
Biological sexAll
Age18-70
SponsorZhejiang University
About this trial
The goal of this observational study is to determine the incidence and spectrum of opportunistic infections among Chinese HIV/AIDS patients at this stage, to find intervention targets, to construct an early warning prediction model, and to give an individualized program with integrated immune function to obtain salvage opportunities for patients.The main questions it aims to answer are:
* Describe the populations and characteristics of pathogenic microorganisms involved in HIV co-infection, map the spatial and temporal changes in the infection system of pathogenic microorganisms, and evaluate their impact on disease regression. * Explore the mechanism of interaction between pathogenic microorganisms and host autoimmune deficiencies. * Discover early warning and predictive markers and immunological indicators of pathogenic microorganisms, and explore new technologies and programs to reduce the mortality rate of infection.
Eligibility criteria
This trial does not accept healthy volunteersQualifiers
Sign the informed consent form.
HIV positive.
Any gender, age 18 to 70 years old
Disqualifiers
None
Trial population
HIV/AIDS patients
Trial design
Design model
Cohort
Time perspective
Prospective
Treatments tested in this trial
Not listed
Trial groups
No trial groups listed
Trial outcomes
Primary outcomes
1
Secondary infections in patients with HIV/AIDS at 4 weeks
Site of infection, pathogen results such as blood or body fluid pathogen cultures or Next-generation sequencing(NGS) results.
Time frame
4 weeks2
quick SEPSIS RELATED ORGAN FAILURE ASSESSMENT(qSOFA) at 4 weeks
qSOFA consists of 3 items: altered state of consciousness, systolic blood pressure ≤ 100 mmHg, and respiratory rate ≥ 22 respirations/min. 2 or more items, i.e., a qSOFA score of ≥ 2, are considered to be suspicious for sepsis.Higher qSOFA scores are associated with a higher risk of patient death.
Time frame
4 weeksSecondary outcomes
1
Survival rate
12-week survival in patients with HIV/AIDS co-infection with secondary infections.
Time frame
12 weeksLocations
Sponsors and contacts
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Zhejiang University
Lead sponsor
Beijing Ditan Hospital
Collaborator
Beijing YouAn Hospital
Collaborator
Huashan Hospital
Collaborator
Qilu Hospital of Shandong University
Collaborator
Source ClinicalTrials.gov
This trial is not recruiting at the moment. You can still explore other options: