To estimate the prevalence of histologically confirmed early gastric cancer (EGC) in an Indian multicentre cohort undergoing standardised high-quality upper gastrointestinal endoscopy. EGC is defined as gastric adenocarcinoma confined to the mucosa or submucosa (T1), irrespective of lymph node status, based on histopathology.
Adults aged ≥40 years undergoing upper gastrointestinal endoscopy for dyspepsia or other clinical indications (nonalarming and alarming symptoms both).
Ability to provide written informed consent.
Known gastric malignancy.
Prior gastric surgery (excluding H. pylori eradication).
Contraindications to endoscopy or biopsy.
Known hereditary gastric cancer syndromes.
4,000
Other
Cross-sectional
Not listed
Prevalence of histologically confirmed early gastric cancer
Prevalence (proportion) of histologically confirmed early gastric cancer (EGC) detected on biopsy or endoscopic resection specimen during the endoscopy.
Prevalence of gastric precancerous lesions
Prevalence and distribution of gastric precancerous lesions, including: Atrophic gastritis, Intestinal metaplasia (EGGIM positive: Yes/No; and histologic IM/OLGIM), Low-grade dysplasia (LGD), High-grade dysplasia (HGD), Advanced precancerous phenotype (OLGIM III-IV and/or HGD)
Clinical and demographic predictors
Predictors of precancerous lesions
Endoscopy-pathology concordance
Endoscopy-pathology concordance, including concordance between: Endoscopic suspicion and histology
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