A Multicentre Study of Wastewater and Antibiotic Resistance in Care Homes.
ConditionAntimicrobial Resistance
Trial statusRecruiting
Trial phaseNot listed
Trial typeObservational
Biological sexAll
Age18+
SponsorNantes University Hospital
About this trial
This study aims to model the relationship between the prevalence of ESBL-E and CPE carriage among nursing home residents and their respective concentrations in wastewater discharged from the facility.
Eligibility criteria
This trial does not accept healthy volunteersQualifiers
Residents present on the day of sampling (D0 or D+1) in a facility selected during randomization, without criteria regarding length of stay in the facility, and whose health status on the day of the survey permits it;
Residents who, based on clinical criteria (including an MMSE greater than or equal to 20), are deemed by the nursing home team to be able to understand the issues of the study and to express an informed non-opposition; OR Residents who the nursing home team considers unable to express an informed non-objection but who have a legal representative, a trusted person, or a loved one capable of understanding the information and expressing an informed non-objection.
Disqualifiers
Residents whose health status is incompatible with performing the procedure on the day of the survey (e.g., end-of-life with comfort care);
Residents with a Mini Mental State Examination (MMSE) score of less than or equal to 20, or without an MMSE score but who, according to nursing home professionals, are unable to provide an informed non-objection and who do not have a legal representative, trusted person, or relative capable of receiving information and providing an informed non-objection;
Residents, regardless of their MMSE score, who refuse to have the sample taken on the day of the survey even if their legal repre
Trial population
Nursing home residents located in Loire-Atlantique and Maine-et-Loire, France
Trial design
Design model
Cohort
Time perspective
Cross-sectional
Treatments tested in this trial
Not listed
Trial groups
No trial groups listed
Trial outcomes
Primary outcomes
1
Predictive performance
The primary endpoint will be the adequacy and predictive performance of the model for estimating the prevalence of ESBL-E/CPE carriage among nursing home residents. Carriage prevalence will be measured by collecting stool samples from residents or, failing that, by anorectal swabs.
Time frame
15 monthsSecondary outcomes
1
Epidemiology of ESBL/CPE in nursing homes
To assess the prevalence of residents carrying ESBL and CPE in the population of nursing home residents in Loire-Atlantique and Maine-et-Loire * Model the relationship between infected residents, ESBL carriers on the one hand, and CPE on the other, and the concentration in wastewater * To analyze the factors associated with the prevalence of EBLSE and CPE
Time frame
15 monthsSponsors and contacts
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Source ClinicalTrials.gov