A Pilot Study: Micro and NanoPlastics in Association With Crohn's Disease
ConditionCrohn's Disease (CD)
Trial statusNot yet recruiting
Trial phaseNot listed
Trial typeObservational
Biological sexAll
Age18-80
SponsorMak Wing Yan
About this trial
Micro and nanoplastics (MNPs) are environmental contaminants found in food and water. Recent evidence suggests these particles may be linked to intestinal inflammation and changes in gut bacteria, which are key features of Crohn's Disease (CD). This study aims to investigate if patients with Crohn's Disease have a reduced ability to clear these plastic particles and how this affects their immune system and intestinal health.
Eligibility criteria
This trial does not accept healthy volunteersQualifiers
Age 18-80 years
Confirmed diagnosis of Crohn's disease (for cases)
Ability to provide informed consent.
Age 18-80 years old
Disqualifiers
Antibiotic/probiotic use within 4 weeks
History of gastrointestinal malignancy
Presence of stoma
Currently Pregnant
Trial population
Potential subjects will be identified at the Department of Medicine and Therapeutics of the Prince of Wales Hospital, or by personal referral from staff.
Trial design
Design model
Case-control
Time perspective
Cross-sectional
Treatments tested in this trial
Not listed
Trial groups
90 Participants
are grouped into 2 trial groupsGroup A: CD group
Group B: Control group
Trial outcomes
Primary outcomes
1
Micro- and nanoparticle abundance between subjects with Crohn's Disease and controls
Blood sample and intestinal biopsy specimens will be collected to perform micro and nanoplastics quantification.
Time frame
Cross-sectional when the blood sample and the intestinal biopsy are collected.Secondary outcomes
1
Plastic-degrading gene [PDG] abundance between subjects with Crohn's Disease and controls.
Blood and stool samples, as well as intestinal biopsy specimens will be collected to perform fecal DNA extraction, metagenomic sequencing and Plastic-Degrading Genes (PDG) analysis.
Time frame
Cross-sectional when the stool, blood sample and the intestinal biopsy are collected.Sponsors and contacts
Click on the lead sponsor to view all of their trials.
Mak Wing Yan
Lead sponsor
Chinese University of Hong Kong
Sponsor institution
Source ClinicalTrials.gov
This trial is not recruiting at the moment. You can still explore other options: