A Prediction Model of Prolonged Mechanical Ventilation Following Acute Type A Aortic Dissection Surgery

Trial statusNot yet recruiting
Trial phaseNot listed
Trial typeObservational
Biological sexAll
Age18-18
SponsorChina-Japan Friendship Hospital

About this trial

The goal of this observational study is to develop and validate a predictive model for prolonged mechanical ventilation (PMV) following acute type A aortic dissection (ATAAD) surgery.

The main questions it aims to answer are:

1. To validate the predictive performance of the model for PMV after ATAAD surgery 2. To assess the proportion of PMV among patients undergoing ATAAD surgery 3. To evaluate the ICU length of stay and operative mortality in patients with PMV following ATAAD surgery

Eligibility criteria

This trial does not accept healthy volunteers

Qualifiers

Age ≥18 years;

Diagnosis of acute type A aortic dissection (ATAAD) confirmed by computed tomography angiography and echocardiography;

Patients who underwent aortic surgery requiring cardiopulmonary bypass (CPB), were admitted to the surgical intensive care unit (SICU), and received mechanical ventilation.

Disqualifiers

Reintubation;

Intraoperative death or failure to survive beyond 72 hours postoperatively;

Pregnancy;

Severe comorbidities (e.g., lung cancer);

Trial population

ATAAD postoperative patients admitted to SICU

Trial design

Design model

Cohort

Time perspective

Retrospective

Treatments tested in this trial

Not listed

Trial groups

1,400 Participants
are grouped into 2 trial groups
Group A: Development cohort
Group B: Validation cohort

Trial outcomes

Primary outcomes

1

The predictive performance of the model for prolonged mechanical ventilation (PMV) following acute type A aortic dissection (ATAAD) surgery

The predictive performance of PMV following ATAAD surgery includes its discriminative ability and calibration ablility.

Time frame
72 hours after ATAAD surgery
2

The proportion of patients with PMV

The proportion of patients with PMV refers to the proportion of patients with PMV among the total included ATAAD postoperative patients. PMV is defined as postoperative mechanical ventilation lasting more than 72 hours

Time frame
72 hours after ATAAD surgery

Secondary outcomes

1

ICU length of stay (ICU-LOS)

ICU length of stay was defined as the length of time spent in ICU from surgery to discharge or death.

Time frame
From surgery to discharge or death, whichever came first, assessed up to 6 months
2

surgery-related mortality

surgery-related mortality encompassed any death occurring during the index hospitalization (even beyond 30 days) or after discharge but before postoperative day 30.

Time frame
30 days after ATAAD surgery

Other outcomes

Sponsors and contacts

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