The purpose of the study is to examine the effect of Problem Adaptation Therapy for Pain (PATH-Pain) on cognitive functioning, depression and pain-related disability in 100 older adults with cognitive impairment, chronic pain, and depression. The study will test if PATH-Pain has better cognitive, affective, and functional outcomes than Attention Control Usual Care.
Age ≥ 60 years old
MCI or early stage probable or possible AD diagnosis (as defined by Albert et al or McKhann et al) al). Patients will have at least mild cognitive deficits defined by 16 ≤ MoCA ≤ 25.
Montgomery Asberg Depression Rating Scale (MADRS)[55] total ≥ 5, which reflects at least some mild depressive symptoms.
Participants will be off antidepressants, cholinesterase inhibitors or memantine or on a stable dosage for at least 12 weeks.
Deemed to have a significant suicide risk as assessed by site PI and clinical team.
Deemed too unstable medically or neurologically to safely enroll in a research trial.
Deemed too psychiatrically unstable to safely enroll in randomized trial of psychotherapy.
Requiring psychiatric hospitalization at baseline for safety.
Weill Medical College of Cornell University
Lead sponsor
National Institute on Aging (NIA)
Collaborator