This project conducts a prospective cohort study. By using multiple questionnaire survey methods such as the Pittsburgh Sleep Quality Index (PSQI) electronic wristband, QOR15, Pain Catastrophizing Scale (PCS), European Five-Dimensional Health Scale (EQ-5D), Revised American Pain Society Patient Follow-up Questionnaire (APS-POQ-R), Mini-Mental State Examination (MMSE), as well as perioperative stress and related indicators, hypothalamic-pituitary-adrenal axis (HPA) endocrine indicators, sublingual microcirculation, electroencephalogram, etc., comprehensive assessment is made of the correlations between the two different anesthesia methods of Tubeless retention of spontaneous breathing and double-lumen bronchial intubation and postoperative sleep, chronic pain and cognitive function, to construct a perioperative brain health safety system to improve prognosis; at the same time, optimize the perioperative sedation and analgesia plan and promote the postoperative brain health recovery of patients.
Patient age: 18 - 75 years old
Patients meeting the standards of the American Society of Anesthesiologists (ASA) I-III grade and the New York Heart Association (NYHA) I-II class
Body Mass Index (BMI) < 30 kg/m2
Intraoperative blood loss less than 300 ml
Already diagnosed with a mental disorder or had a preoperative Mini-Mental State Examination (MMSE) score of less than 27
History of opioid abuse
Patients who were admitted to the ICU after surgery
Have severe cardiovascular, respiratory diseases
Patients who underwent elective non-anatomic partial lung resection surgery at the First Affiliated Hospital of Guangzhou Medical University
Cohort
Prospective
Not listed
Concentration of cognitive function biomarkers in the serum samples of 400 patients
At time points T1, T2, and T3, 5 ml of peripheral venous blood was collected to test the biological indicators of postoperative cognitive function.
Concentrations of HPA axis-related indicators in the serum samples of 400 patients
At the TI-T2 time point, 5 ml of peripheral venous blood was collected for the detection of HPA axis-related indicators.
The concentrations of laboratory test indicators in the serum samples of 400 patients
Record the laboratory test indicators at time points T1 and T3
Anesthesia Record Form
Record the vital signs at the T2 time point
Case information system collection
Record the pulmonary function, chest X-ray or chest CT at time points T1 and T3
Anesthesia Record Form
Record the intraoperative conditions
Postoperative follow-up records
Record the time of chest tube removal after surgery
Postoperative follow-up records
Record the occurrence of adverse events during the perioperative period
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