A Prospective, Observational Study to Evaluate the Safety and Feasibility of Continuous Renal Replacement Therapy With Regional Citrate Anticoagulation in a Cohort Critical Ill Patients With Acute Kidney Injury and Presumed Absent Citrate Metabolism

ConditionAcute Kidney Injury

Trial statusNot yet recruiting

Trial phaseNot listed

Trial typeObservational

Biological sexAll

Age18+

SponsorUniversity Hospital, Antwerp

About this trial

Use of regional citrate anticoagulation in an at risk population with decreased citrate metabolism. This study assesses the feasibility and safety of regional citrate anticoagulation in this population.

Eligibility criteria

Qualifiers

anticipation of severely impaired citrate metabolism (serum lactate ≥ 5 mmol/l in patients with shock or requirement of a dextrose drip to prevent hypoglycemia or spontaneous INR > 3 and/or requirement of fresh frozen plasma to maintain INR < 3 in patients with cirrhosis or acute liver failure or acute on chronic liver failure)

development of citrate toxicity under CRRT with RCA due to worsening citrate metabolism

Disqualifiers

Pregnancy

A known hypersensitivity to citrate compounds

Refusal of informed consent

Trial design

Treatments tested in this trial

continuous renal replacement therapy with regional citrate anticoagulation

Treatment groups

50 Participants

are divided into 1 treatment group

Sponsors and collaborators

University Hospital, Antwerp

Lead sponsor

Source ClinicalTrials.gov