A Prospective Study Evaluating the Impact of Conservative Management on Retained Products of Conception and EMV

Trial statusRecruiting
Trial phaseNot listed
Trial typeObservational
Biological sexFemale
AgeNot listed
SponsorFu Xing Hospital, Capital Medical University

About this trial

The goal of this observational study is to learn about the therapeutic effects of the conservative treatment approach on pepole with retained products of conception (RPOC) and Enhanced myometrial vascularity (EMV).

The main question it aims to answer is: Is it possible to achieve the natural resolution of RPOC by combining it with EMV through conservative treatment? Participants will receive conservative treatment (such as mifepristone, GnRH-a, or expectant management) following the initial diagnosis of RPOC and EMV, and the therapeutic efficacy of the conservative approach will be assessed after the completion of two menstrual cycles.

Eligibility criteria

This trial does not accept healthy volunteers

Qualifiers

Recent history of miscarriage or delivery (within the past 8 weeks)

Strong willingness to undergo conservative management

Hemodynamically stable

Signed informed consent form

Disqualifiers

Heavy vaginal bleeding (requiring immediate surgical intervention)

Active pelvic or systemic infection (e.g., fever >38°C, elevated CRP/WBC)

Severe dysfunction of vital organs (heart, liver, or kidney)

Known drug allergies or contraindications to proposed medications (e.g., misoprostol intolerance)

Trial population

Study population of who visited the outpatient department of the hysteroscopy center of our hospital from October 2024 to October 2026 and were provisionally diagnosed as " retained products of conception (RPOC)" based on their history and symptoms.

Trial design

Design model

Cohort

Time perspective

Prospective

Treatments tested in this trial

Not listed

Trial groups

No trial groups listed

Trial outcomes

Primary outcomes

1

The disappearance rate of RPOC

The definition of "the disappearance rate of RPOC" refers to the absence of significant residual trophoblastic tissue as indicated by ultrasound examination

Time frame
After conservative treatment, transvaginal ultrasound was performed at the end of the second menstrual cycle (calculated from the first day of menses, 28-30 days per cycle) to assess RPOC resolution

Secondary outcomes

1

the disappearance rate of EMV

The definition of "the disappearance rate of EMV" refers to a PSV (Peak Systolic Velocity) of less than 20 cm/s or its complete disappearance as indicated by Ultrasound Doppler examination.

Time frame
Immediately after the completion of conservative treatment

Other outcomes

Sponsors and contacts

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