About this trial
The goal of this observational study is to learn about the therapeutic effects of the conservative treatment approach on pepole with retained products of conception (RPOC) and Enhanced myometrial vascularity (EMV).
The main question it aims to answer is: Is it possible to achieve the natural resolution of RPOC by combining it with EMV through conservative treatment? Participants will receive conservative treatment (such as mifepristone, GnRH-a, or expectant management) following the initial diagnosis of RPOC and EMV, and the therapeutic efficacy of the conservative approach will be assessed after the completion of two menstrual cycles.
Eligibility criteria
This trial does not accept healthy volunteersQualifiers
Recent history of miscarriage or delivery (within the past 8 weeks)
Strong willingness to undergo conservative management
Hemodynamically stable
Signed informed consent form
Disqualifiers
Heavy vaginal bleeding (requiring immediate surgical intervention)
Active pelvic or systemic infection (e.g., fever >38°C, elevated CRP/WBC)
Severe dysfunction of vital organs (heart, liver, or kidney)
Known drug allergies or contraindications to proposed medications (e.g., misoprostol intolerance)
Trial population
Study population of who visited the outpatient department of the hysteroscopy center of our hospital from October 2024 to October 2026 and were provisionally diagnosed as " retained products of conception (RPOC)" based on their history and symptoms.
Trial design
Cohort
Prospective
Treatments tested in this trial
Not listed
Trial groups
Trial outcomes
Primary outcomes
The disappearance rate of RPOC
The definition of "the disappearance rate of RPOC" refers to the absence of significant residual trophoblastic tissue as indicated by ultrasound examination
Secondary outcomes
the disappearance rate of EMV
The definition of "the disappearance rate of EMV" refers to a PSV (Peak Systolic Velocity) of less than 20 cm/s or its complete disappearance as indicated by Ultrasound Doppler examination.
Sponsors and contacts
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