About this trial
This study aims to investigate the best strategy for repeat ablation of recurrent persistent atrial fibrillation (AF) after previous persistent AF ablation involving pulmonary vein isolation (PVI) along. Patients with low voltage areas on the posterer wall will be randomized to PVI alone or the posterer wall isoaltion (PWI) in addition to PVI.
Eligibility criteria
This trial does not accept healthy volunteersQualifiers
Symptomatic patients with persistent AF and indication for repeat ablation
procedure.
Patients with recurrent persistent AF (with a duration <3 year, at least one episode longer than 7 days during the last 6 months and have been electrically cardioverted at least once during the last 12 months) after previous catheter ablation.
Patients with up to two previous catheter ablations for AF are included if the procedures only involved PVI. Previous PVI procedure(s) with both cryoablation and radiofrequency ablation are accepted.
Disqualifiers
Patients with >2 ablation procedures in the LA for AF or atrial flutter
Previous ablation procedures for AF involving ablation strategies beyond PVI
Duration of persistent AF >3 years
Presence of atrial flutter or atrial tachycardia
Trial design
Parallel
Treatments tested in this trial
Radio frequency ablation
Procedure/SurgeryRadio frequency ablation
Treatment groups
Trial outcomes
Primary outcomes
Atrial tachyarrhythmias with duration >30 seconds
Alle episodes of atrial tachyarrhythmia (atrial fibrillation, atrial flutter of atrial tachycardia) with duration \>30 seconds recorded 3-months after the ablation procedure will be regarded as recurrence. Blanking period is defined as 3 months.
Secondary outcomes
Complications and adverse events
All periprocedural complications and adverse events during follow-up
Procedure time
Procedure time will be recorded and reported.
Ablation time
Ablation time will be recorded and reported.
Fluoroscopy time
Fluoroscopy time will be recorded and reported.
Locations
Sponsors and contacts
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Haukeland University Hospital
Lead sponsor
St. Olavs Hospital
Collaborator
University Hospital of North Norway
Collaborator
This trial is not recruiting at the moment. You can still explore other options: