This is a single-center, non-interventional, observational, cross-sectional clinical study designed to quantitatively and qualitatively characterize skin properties in a cohort of 100 Chinese female Subjects aged 20 to 70 years. The study involves no product application and poses minimal risk to participants. The primary objectives are to establish a comprehensive skin aging profile database, characterize skin color, aging signs, and biomechanical properties, and create a histomorphometric database for the development and validation of ordinal photographic scales for aging research. Data will be collected through questionnaires, clinical assessments (including LC-OCT imaging), standardized photography, and non-invasive biophysical measurements. All procedures will be conducted in accordance with the ethical principles originating from the Declaration of Helsinki, the International Council for Harmonisation Good Clinical Practice (ICH-GCP) guidelines, and the relevant laws and regulations of China (including the \*Measures for the Ethical Review of Biomedical Research Involving Human Subjects\*). All data will be anonymized and stored securely.
Chinese female, aged between 20 and 70 years (inclusive) at the time of signing consent.
Willing and able to provide written informed consent.
Fitzpatrick Skin Phototype II or III.
Willing to comply with all study procedures, including removal of facial makeup and avoidance of intensive skincare (e.g., retinoids, strong acids) on the test areas for 3 days prior to the visit as per instructions.
Pregnant, planning pregnancy, or breastfeeding (as hormonal changes significantly affect skin properties).
Presence of temporary tanning, sunburn, or significant erythema on the face or measurement areas.
Presence of facial piercings, tattoos, too much fluff or significant scarring that would interfere with imaging or measurements in the areas of interest.
History of any aesthetic or surgical procedure on the face (e.g., laser therapy, chemical peels, injectable fillers, botulinum toxin, plastic surgery) within the past 12 months.
Approximately 100 healthy Chinese female Subjects, evenly distributed across age groups (20-29, 30-39, 40-49, 50-59, 60-70 years).
Cohort
Cross-sectional
Not listed
Epidermal Thickness
Dermal-Epidermal Junction (DEJ) Undulation Index
Mean Dermal Reflectivity
Stratum Corneum Thickness
Clinician-graded score of skin texture/pores
Clinician-graded score of skin pigmentation
Clinician-graded score of facial wrinkles
