A Registered Cohort Study on Wilson's Disease
ConditionWilson's Disease
Trial statusRecruiting
Trial phaseNot listed
Trial typeObservational
Biological sexAll
AgeNot listed
SponsorWan-Jin Chen
About this trial
The aim of this study is to determine the clinical spectrum and natural progression of Wilson's Disease in a prospective multicenter natural history study, to assess the clinical, genetic, epigenetic features and biomarkers of patients with Wilson's Disease to optimize clinical management.
Eligibility criteria
This trial accepts healthy volunteersQualifiers
Patients with the genetic diagnosis of Wilson's Disease
Asymptomatic Wilson's Disease carriers
Relatives of Wilson's Disease patients or carriers
Unrelated healthy controls
Disqualifiers
None
Trial population
Patients with Wilson's Disease are diagnosed by the clinical and/or genetic features
Trial design
Design model
Cohort
Time perspective
Prospective
Treatments tested in this trial
No intervention
Other interventionNo intervention
Treatment groups
2,000 Participants
are divided into 4 treatment groupsGroup A: Patients with the genetic diagnosis of Wilson's Disease1 intervention
Group B: Asymptomatic Wilson's Disease carriers1 intervention
Group C: Relatives of Wilson's Disease patients or carriers1 intervention
Group D: Unrelated healthy controls1 intervention
Trial outcomes
Primary outcomes
1
The change of Unified Wilson's Disease Rating Scale (UWDRS)
Disease severity will be assessed by application of the Unified Wilson's Disease Rating Scale (UWDRS), a clinical rating scale consists of three subscales. Higher UWDRS total scores indicate more severe disease.
Time frame
Up to 30yearsSponsors and contacts
Click on the lead sponsor to view all of their trials.
Wan-Jin Chen
Lead sponsor
First Affiliated Hospital of Fujian Medical University
Sponsor institution
Source ClinicalTrials.gov