A Registry Study of Microcirculation Disorder After Cerebral Small Vessel Disease and Ischemic Stroke
Trial statusNot yet recruiting
Trial phaseNot listed
Trial typeObservational
Biological sexAll
Age18+
SponsorBeijing Tiantan Hospital
About this trial
This study aims to construct a registry platform for microcirculatory disorders in a large sample of Chinese patients with cerebral small vessel disease and ischemic stroke; To explore the role of microcirculatory disorders in different types of cerebral small vessel disease and iachemic stroke, as well as their pathogenesis, severity, and prognosis; And to research on the drug treatment of microcirculatory disorders for cerebral small vessel disease and stroke in the real world.
Eligibility criteria
This trial does not accept healthy volunteersQualifiers
Age ≥ 18 years old.
Acute ischemic stroke within 7 days of onset.
Sign an informed consent form.
Age ≥ 18 years old.
Disqualifiers
Cerebral hemorrhage and subarachnoid hemorrhage within 3 months of onset.
There are untreated cerebral vascular malformations or untreated aneurysms (diameter>3mm).
Confirmed neurodegenerative diseases such as Alzheimer's disease, Parkinson's disease, Parkinson's syndrome, etc.
A mental illness diagnosed according to the DSM-V diagnostic criteria.
Trial population
Study 1: Patients with acute ischemic stroke. Study 2: Patients with ischemic stroke during the recovery period. Study 3: Patients with cerebral small vessel disease based on STRIVE classification.
Trial design
Design model
Cohort
Time perspective
Prospective
Treatments tested in this trial
Not listed
Trial groups
20,000 Participants
are grouped into 3 trial groupsGroup A: Registry Study on Microcirculatory Disorders in Acute Ischemic Stroke
Group B: Registry Study on Microcirculatory Disorders in Ischemic Stroke during Recovery Period
Group C: Registry Study on Microcirculatory Disorders in CSVD
Trial outcomes
Primary outcomes
1
The correlation between microcirculatory disorders and recurrence of stroke (ischemic stroke and hemorrhagic stroke)
This study will collect disease information related to microcirculatory disorders and recurrent stroke among patients with acute ischemic stroke.
Time frame
baseline, 14th day, 3rd month, 6th month, 12th month, 18th month, 24th month2
Correlation between microcirculatory disorders and daily living ability levels (mRS) in patients with acute ischemic stroke
This study will collect disease information related to microcirculatory disorders and mRS among ischemic stroke patients during recovery period.
Time frame
baseline, 3rd month, 6th month, 12th month, 18th month, 24th month3
The correlation between microcirculatory disorders and cognitive function in CSVD (Mini COG).
This study will collect disease information related to microcirculatory disorders and Mini COG among patients with CSVD.
Time frame
baseline, 3th month, 12th monthSecondary outcomes
1
The drug treatment of acute ischemic stroke in the real world based on microcirculation disorders.
Record all the medication treatment information during the follow-up period since the last visit, and all the medications information is collated to describe the patient's medication regimen.
Time frame
baseline, 14th day, 3rd month, 6th month, 12th month, 18th month, 24th month2
The correlation between microcirculatory disorders and the combination of vascular events (ischemic stroke, hemorrhagic stroke, myocardial infarction, vascular death) in the recovery period of ischemic stroke.
This study will collect Major Adverse Cardiovascular Events (MACE): including ischemic stroke, hemorrhagic stroke, myocardial infarction, and vascular death.
Time frame
baseline, 14th day, 3rd month, 6th month, 12th month, 18th month, 24th month3
The correlation between microcirculatory disorders and the pathogenesis of acute ischemic stroke with different etiological subtypes.
Record the final diagnosis and main combined diagnosis of this enrollment event and complete blood laboratory examination, transcranial doppler ultrasound examination, physical examination and the like to ensure and evaluate the correlation between microcirculatory disorders and the pathogenesis of recovery ischemic stroke in different etiological subtypes.
Time frame
baseline, 3rd month, 12th month4
The correlation between microcirculation disorders and the severity of acute ischemic stroke.
This study will collect disease information related to microcirculatory disorders among patients with acute ischemic stroke to evaluate the correlation between microcirculation disorders and the severity of acute ischemic stroke.
Time frame
baseline, 3rd month, 12th monthSponsors and contacts
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Source ClinicalTrials.gov
This trial is not recruiting at the moment. You can still explore other options: