About this trial
This clinical trial is being conducted to see if brain stimulation and brain training together improves cognitive functioning and mood in older adults diagnosed with Mild Cognitive Impairment (MCI). Brain stimulation will be done using repetitive Transcranial Magnetic Stimulation (rTMS). Brain training will be done using immersive virtual reality cognitive training (iVCT) program. The goals of this clinical trail are as follows:
* Examine if rTMS+iVCT intervention can improve and sustain objective cognitive functioning in individuals with MCI more than control or rTMS only groups * Examine if rTMS+iVCT intervention improves participants mental health symptoms, functional abilities, and quality of life more than control or rTMS only groups * Examine the impact of rTMS+iVCT intervention on caregiver burden.
Eligible participants will be assigned to a standard treatment (no intervention control) group, rTMS only group of rTMS+iVCT group. All participants will undergo baseline assessment to evaluate their cognitive, emotional, and functional abilities. Those in the rTMS only group will receive rTMS treatments for five days per week for two weeks (total of ten sessions). Those in the rTMS+iVCT group will receive rTMS treatment followed by iVCT training for five days a week for two weeks (total of ten sessions). All participants will then repeat testing 2 weeks and three months after baseline testing to assess for possible treatment related changes and lasting effects.
Eligibility criteria
This trial accepts healthy volunteersQualifiers
age 55 and over
previous diagnosis of Mild Cognitive Impairment
Score of 18 or over on the MoCA during pre-screening procedures.
Disqualifiers
below 55 years old
Do not pass the TMS Adult Safety Screening
Taking medications known to increase risk of seizure
Taking ototoxic medications
Trial design
Parallel
Treatments tested in this trial
rTMS
DeviceTranscranial Magnetic Stimulation
rTMS+iVCT
DeviceTranscranial Magnetic Stimulation and immersive virtual reality
Treatment groups
Trial outcomes
Primary outcomes
Change in Hopkins Verbal Leaning Test Standard Score
range: \<55 to \>130 - higher score is improvement
Secondary outcomes
Change in NPI
Range: 0-33 Lower score is improvement
Change in Functional Activities Questionnaire score
Range: 0-30 Lower score is improvement
Sponsors and contacts
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