A Study of Lung Cancer Screening in People With Unexplained Weight Loss
ConditionLung Cancer Screening
Trial statusRecruiting
Trial phaseNot listed
Trial typeObservational
Biological sexAll
Age50-80
SponsorMemorial Sloan Kettering Cancer Center
About this trial
The researchers are doing this study to see if people with unexplained weight loss who have lung cancer screening are more likely to have or develop lung cancer than people without unexplained weight loss. The lung cancer screening will involve use of low-dose computed tomography (LDCT), a CT scan that gives off very low doses of radiation and can make detailed pictures of the lungs to help find tumors. The study researchers will also analyze participants' blood samples to determine if blood testing can be used to help to diagnose lung cancer.
Eligibility criteria
This trial accepts healthy volunteersQualifiers
Age 50-80 years old
At least 20-pack year history of smoking
Weight loss of 3-10%, defined as UWL, within any timeframe over the past in the 18 months prior to enrollment, that cannot be attributed to an underlying medical condition at the discretion of the enrolling investigator
Note that patients who have 3-10% weight may still be enrolled if the enrolling investigator does not conclude that the weight loss can be attributed to the patient's intentional efforts.
Disqualifiers
Currently pregnant or trying to become pregnant via self-report
Prior history of recent CT scan of the chest either through LDCT screening or with a scan of the chest (standard, not LDCT) performed within the past 12 months
Prior history of NSCLC
Currently undergoing or referred for diagnostic evaluation due to clinical suspicion for malignancy (e.g., referred to a medical or surgical oncologist, or scheduled for biopsy on the basis of a suspicious imaging abnormality).
Trial population
Potential research subjects will be identified at MSKCC largely through survivorship clinics.
Trial design
Design model
Cohort
Time perspective
Prospective
Treatments tested in this trial
Low Dose CT imaging
Diagnostic testat baseline and at Year 1.
blood draws
Other interventionat baseline and at Year 1.
screening questionnaire
Other interventionat baseline and at 1 year after registration.
Treatment groups
409 Participants
are divided into 1 treatment groupGroup A: Patients undergoing Lung cancer screening3 interventions
Trial outcomes
Primary outcomes
1
The incidence of lung cancer in patients with unexplained weight loss
Low Dose CT screening
Time frame
2 yearsSponsors and contacts
Click on the lead sponsor to view all of their trials.
Memorial Sloan Kettering Cancer Center
Lead sponsor
AstraZeneca
Collaborator
Source ClinicalTrials.gov