A Study of Magnetic Resonance Imaging of the Pancreas for Cancer Screening
Trial statusRecruiting
Trial phaseNot listed
Trial typeObservational
Biological sexAll
Age18+
SponsorMemorial Sloan Kettering Cancer Center
About this trial
The purpose of this study is to develop a dedicated MRI scan of the pancreas (MRP) to better detect pancreatic cancer in people who are at a high risk for pancreatic cancer.
Eligibility criteria
This trial does not accept healthy volunteersQualifiers
Two first-degree relatives with pancreas cancer, one being a first-degree relative to the individual
Pathogenic mutation in APC, BRCA1, MLH1, MSH2, MSH6, PMS2, EPCAM, PALB2, or TP53 and a first/second-degree relative with pancreas cancer
Pathogenic mutation in CDKN2A/p16, STK11, PRSS1, SPINK1/PST1, CTRC, CPA1, ATM, or BRCA2
Meets surveillance age eligibility, which is typically age 50, or 10 years earlier than the youngest relative with pancreas cancer. For individuals with certain gene mutations, this can be earlier. All participants must be aged 21+
Disqualifiers
None
Trial population
Investigators will conduct this pilot study in high-risk individuals enrolled in the Memorial Sloan Kettering Pancreatic Tumor Registry
Trial design
Design model
Cohort
Time perspective
Prospective
Treatments tested in this trial
MRI
Diagnostic testParticipants will undergo a single MRI of the abdomen without contrast
Endoscopic ultrasound
Diagnostic testEUS will be scheduled the same day or within 2 weeks prior to MRP
Treatment groups
79 Participants
are divided into 1 treatment groupGroup A: Participants at high risk for pancreas ductal adenocarcinoma2 interventions
Trial outcomes
Primary outcomes
1
Compare image quality of novel high-resolution magnetic resonance pancreas (MRP) to conventional MRCP
Develop and pilot a focused high-resolution magnetic resonance pancreas (MRP) exam to help facilitate early pancreatic cancer detection in high-risk individuals. Image quality for T1, T2, and DWI sequences performed on the novel MRP exam will be compared to conventional MRCP performed in the same participants.
Time frame
Up to 3 yearsSponsors and contacts
Click on the lead sponsor to view all of their trials.
Memorial Sloan Kettering Cancer Center
Lead sponsor
National Institutes of Health (NIH)
Collaborator
Source ClinicalTrials.gov