A Study of Microcirculatory Function in Type 2 Myocardial Infarction (T2MI)

ConditionsMyocardial Infarction Coronary Microvascular Disease

Trial statusNot yet recruiting

Trial phaseNot listed

Trial typeObservational

Biological sexAll

Age18+

SponsorMayo Clinic

About this trial

The purpose of this research is to find out if patients with Type 2 Myocardial Infarction (T2MI) without significant epicardial coronary artery disease (CAD) have a greater chance of having coronary microvascular disease (CMD).

Eligibility criteria

This trial does not accept healthy volunteers

Qualifiers

Ability to give informed consent

Structurally normal heart (normal LV and RV function, no more than mild valvular heart disease)

For controls: atypical chest pain with indication for CMD testing

For T2MI: meet criteria for T2MI according to the 4th Universal definition of MI (rise/fall of troponin with at least 1 value >99th centile+ evidence of symptoms or signs of myocardial ischemia)

Disqualifiers

Acute coronary event (evidence of plaque rupture, fissure or dissection on coronary angiogram)

Known to have angiographically significant CAD/pressure wire positive for epicardial CAD

Inability to receive heparin products

Allergy/contraindication to acetylcholine/adenosine/nitroglycerine products

Trial population

Subjects receiving care at Mayo Clinic in Rochester, MN identified with T2MI and controls with atypical chest pain with indication for CMD testing will be enrolled in this study. Both groups will have no epicardial coronary stenosis \>50% or obstructive disease.

Trial design

Design model

Case-control

Time perspective

Cross-sectional

Treatments tested in this trial

Coronary angiogram with coronary reactivity testing (CRT)
Diagnostic test
CRT is an angiography procedure (using X-ray) to examine the small blood vessels in the heart and how they respond to three drugs (adenosine, acetylcholine and nitroglycerin) as per clinical protocol.

Treatment groups

52 Participants

are divided into 2 treatment groups

Group A: T2MI Patients1 intervention

Group B: Controls0 interventions

Trial outcomes

Primary outcomes

Coronary Flow Reserve (CFR)

The CFR will be calculated as a ratio of coronary flow at peak hyperemia /coronary flow at rest.

Time frame

Baseline

Secondary outcomes

Backward Compression Wave (BCW)

The BCW is a measure of increased microvascular resistance during systole.

Time frame

Baseline

Sponsors and contacts

Click on the lead sponsor to view all of their trials.

Mayo Clinic

Lead sponsor

Source ClinicalTrials.gov

This trial is not recruiting at the moment. You can still explore other options: