About this trial

The purpose of this study is to develop a unique structure and delivery of home-based exercise through multidisciplinary expertise of cardiovascular medicine specialists and cardiac physiologists using an Interactive Care Plan.

Eligibility criteria

Qualifiers

Intraluminal filling defect in segmental or larger vessels on computed tomography pulmonary angiography or high-probability ventilation/perfusion scan AND

Evidence of right ventricular enlargement by computed tomography (RV to LV ratio >1) or echocardiography; and/or right ventricular dysfunction by transthoracic echocardiography. These imaging characteristics must be in the setting of acute PE rather than explained by a prior chronic condition.

Intraluminal filling defect in segmental or larger vessels on computed tomography pulmonary angiography or high-probability ventilation/perfusion scan AND

Evidence of right ventricular enlargement by computed tomography (RV to LV ratio >1) or echocardiography; and/or right ventricular dysfunction by transthoracic echocardiography. These imaging characteristics must be in the setting of acute PE rather than explained by a prior chronic condition; AND

Disqualifiers

Inability to ambulate independently, which is necessary to perform 6MWD (may be self-reported or as deemed by physical therapy during inpatient evaluation).

If patient requires supplemental oxygen during ambulation, this does not exclude patient from participation and will be noted during eCRF.

Prior history of pulmonary embolism

History of CTEPH or pulmonary arterial hypertension

Trial design

Treatments tested in this trial

Exercise Training

Treatment groups

100 Participants

are divided into 2 treatment groups

A Study of Mobility Outcomes in Post-Pulmonary Embolic Disease