A Study Of Myocardial Stiffness In Amyloidosis With Magnetic Resonance Elastography
ConditionAmyloidosis
Trial statusRecruiting
Trial phaseNot listed
Trial typeObservational
Biological sexAll
Age20+
SponsorMayo Clinic
About this trial
This is a prospective case control study to determine the feasibility and utility of myocardial stiffness assessment by cardiac magnetic resonance elastography (MRE) in patients with cardiac amyloidosis.
Eligibility criteria
This trial does not accept healthy volunteersQualifiers
Adult, age 20 and greater
Subject is clinically stable without cardiovascular-related hospitalizations within 2 weeks prior to enrollment as assessed by the investigators
Subject is able to provide written informed consent and is willing and able to complete study procedures
Disqualifiers
None
Trial population
Participants will be recruited from the Mayo Clinic's Cardiology, Hematology, and Cardiovascular Imaging clinics."
Trial design
Design model
Case-control
Time perspective
Prospective
Treatments tested in this trial
Magnetic Resonance Elastography (MRE)
Diagnostic testPatients will undergo a cardiac MRI with the addition of continuous free-breathing and breath-held MRE sequences.
Treatment groups
20 Participants
are divided into 1 treatment groupGroup A: Cardiac Amyloidosis1 intervention
Trial outcomes
Primary outcomes
1
Percentage of subjects able to complete a Magnetic Resonance Elastography exam
Magnetic Resonance Elastography exam completion will be determined by signal to noise (SNR) ratio
Time frame
Baseline2
Mean Myocardial Stiffness
Mean Myocardial stiffness will be measured by magnetic resonance elastography during early systole, end systole, early diastole and end diastole (kPa).
Time frame
BaselineSponsors and contacts
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Source ClinicalTrials.gov