Health TrialsbyHealthPanel

A Study of SCAD Using Stress Contrast Echocardiography

ConditionSpontaneous Coronary Artery Dissection
Trial statusRecruiting
Trial phaseNot listed
Trial typeObservational
Biological sexAll
Age18+
SponsorMayo Clinic

About this trial

This study aims to fill knowledge gaps regarding microvascular perfusion and pressor response to stress among patients with history of spontaneous coronary artery dissection (SCAD) using stress contrast echocardiography.

Eligibility criteria

This trial accepts healthy volunteers

Qualifiers

Adult >18 years old

Patient has a history of spontaneous coronary artery dissection (SCAD) OR patient is healthy with no significant medical history

Disqualifiers

Unable to give consent

Allergic or have a history of adverse reaction to dobutamine, the Definity® ultrasound enhancing agent, or atropine.

Has a known or suspected hypersensitivity to perflutren and therefore cannot be given Definity®.

Pregnant.

Trial population

Patients will be recruited from the clinic and community.

Trial design

Design model

Case-control

Time perspective

Prospective

Treatments tested in this trial

  • Stress Echocardiography with Contrast

    Procedure/Surgery

    Stress Echocardiography with Contrast will be used to assess heart function and blood flow response to stressors.

Treatment groups

50 Participants
are divided into 2 treatment groups
Group A: Spontaneous coronary artery dissection (SCAD)1 intervention
Group B: Healthy Subjects1 intervention

Trial outcomes

Primary outcomes

1

Change in Microvascular Function

Microvascular Function will be determined by Microvascular Blood Flow (Liters/Minute). Microvascular Blood Flow will be measured by a stress echocardiogram with contrast. A higher Microvascular Blood Flow indicated better blood flow circulation.

Time frame
Baseline, immediately after the Stress Echocardiography
2

Change in Blood Pressure

Change is blood pressure will be measured by a stress echocardiogram with contrast (mmHg).

Time frame
Baseline, immediately after the Stress Echocardiography
3

Change in Heart Rate

Change in heart rate will be measured by a stress echocardiogram with contrast (beats per minute).

Time frame
Baseline, immediately after the Stress Echocardiography

Secondary outcomes

Other outcomes

Sponsors and contacts

Click on the lead sponsor to view all of their trials.

Mayo Clinic

Lead sponsor

National Heart, Lung, and Blood Institute (NHLBI)

Collaborator

Source ClinicalTrials.gov
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