A Study of Taste- and Olfactory-Evoked Potentials in Patients With Visual Impairment: Taste, Smell, and Vision

Trial statusNot yet recruiting
Trial phaseNot applicable
Trial typeInterventional
Biological sexAll
Age18-60
SponsorCentre Hospitalier Universitaire Dijon

About this trial

Visual impairment, whether central or peripheral, may influence the plasticity of other sensory modalities, such as taste and smell. Taste-evoked potentials (TEPs) and smell-evoked potentials (SEPs)-methods for analyzing brain activity in response to taste and smell stimuli-allow for the objective assessment of these interactions. This approach has already demonstrated its value in the study of cognitive disorders. This study aims to demonstrate an enhancement of taste and smell capabilities that could compensate for specific visual impairments, particularly in situations involving food choices.

Eligibility criteria

This trial accepts healthy volunteers

Qualifiers

Adult: ≥ 18 years and ≤ 60 years

Individual who has given oral consent

Individual who has been fasting (no food, drink, or tobacco) for at least 1 hour prior to PEG and PEO measurement

No cognitive complaints and normal neurological examination.

Disqualifiers

Individuals who are not enrolled in or eligible for a social security program

Individuals subject to a legal protective measure (guardianship, conservatorship)

Individuals subject to judicial safeguard measures

Adults who are legally incapacitated or unable to give informed consent

Trial design

Design model

Parallel

Treatments tested in this trial

  • Taste and smell evaluation

    Other intervention

    Determination of taste and smell ability scores using standardized methods (ETOC and Taste Strips)

  • Recording of evoked potentials (EP)

    Other intervention

    A recording of gustatory evoked potentials (GEP) and olfactory evoked potentials (OEP) in response to stimuli consisting of sucrose solution, vanillin, and a combination of the two.

Treatment groups

50 Participants
are divided into 2 treatment groups
Group A: Patients with retinal dystrophy and central or peripheral visual field defectsOther 2 interventions
Group B: Healthy volunteersOther 2 interventions

Trial outcomes

Primary outcomes

1

Average latency of PEG (Taste-Evoked Potentials) peaks

Measurement of the mean latency of taste-evoked potential peaks in visually impaired patients versus control subjects following purely gustatory stimulation (sucrose).

Time frame
At the baseline
2

Average amplitude of PEG (Taste-Evoked Potentials) peaks

Measurement of the mean amplitude of taste-evoked potential peaks in visually impaired patients versus control subjects following purely gustatory stimulation (sucrose).

Time frame
At the baseline

Secondary outcomes

Other outcomes

Sponsors and contacts

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