This observational study aims to investigate the associations between multidimensional human phenotypic characteristics and growth and developmental features. A total of 500 participants aged 6 to 60 years are planned to be enrolled. Multidimensional phenotypic characteristics will be assessed using non-invasive methods, including fingerprint imaging, foot morphology assessment, facial and tongue feature acquisition, anthropometric measurements, and musculoskeletal examinations. Development-related musculoskeletal characteristics, including plantar arch morphology, lower-limb alignment, joint range of motion, and generalized joint mobility, will also be assessed. The collected data will be analyzed to explore associations between external phenotypic characteristics and musculoskeletal growth and developmental features.
Aged 18 to60 years.
Able to understand the study procedures and provide informed consent.
Willing and able to complete the required phenotypic assessments and measurements.
History of surgery that may affect musculoskeletal morphology or function.
Known congenital or developmental disorders that may affect physical growth, limb development, or musculoskeletal morphology.
Unable to complete the required study assessments.
Participants will be young adults aged 18 to 25 years recruited primarily from university populations. Eligible participants will undergo standardized assessments of dermatoglyphic, facial, foot, anthropometric, limb proportional, and joint mobility characteristics.
Cohort
Cross-sectional
Fingerprint Morphological Characteristics
Other interventionFingerprint images of all ten fingers will be collected using a high-resolution fingerprint scanner. Dermatoglyphic characteristics, including fingerprint pattern types (arch, loop, and whorl), total ridge counts, and ridge counts of individual fingers, will be quantitatively and qualitatively assessed. These naturally occurring phenotypic characteristics are observed and measured only, with no intervention assigned to participants.
Foot Arch Morphology Assessed by Arch Index
Foot arch morphology will be assessed using the Arch Index derived from standardized foot measurements. The Arch Index will be used as a quantitative indicator of plantar arch morphology to characterize variations in foot development among participants.
Generalized Joint Hypermobility Assessed by Beighton Score
Generalized joint hypermobility will be assessed using the 9-point Beighton scoring system. The total score ranges from 0 to 9, with higher scores indicating greater generalized joint hypermobility.
Anthropometric and Limb Proportional Measurements
Anthropometric measurements, including height, body weight, upper- and lower-limb lengths, and other relevant body dimensions, will be collected using standardized measurement procedures. Limb proportional indices will be calculated to characterize individual differences in body and limb morphology.
Foot Morphological Characteristics
Foot morphological characteristics will be assessed using standardized foot scanning and measurement procedures. Measures will include foot dimensions and morphological features derived from plantar and foot-shape data to characterize individual variations in foot morphology.
Fingerprint Dermatoglyphic Characteristics
Fingerprint images will be collected using a standardized acquisition procedure. Dermatoglyphic characteristics, including fingerprint pattern types and other morphological features, will be extracted and analyzed to investigate their associations with foot morphology, limb proportions, and generalized joint hypermobility.
Facial Morphological Characteristics
Standardized facial images will be collected under controlled acquisition conditions. Facial morphological characteristics and quantitative facial features will be extracted from the images to characterize individual variations in facial morphology and to investigate their associations with limb and musculoskeletal phenotypes.
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