A Study on Different Treatments for Knee Osteoarthritis Caused by Damaged Roots of the Medial Meniscus.

Trial statusNot yet recruiting
Trial phaseNot listed
Trial typeObservational
Biological sexAll
Age50-65
SponsorShanghai General Hospital, Shanghai Jiao Tong University School of Medicine

About this trial

Medial meniscus posterior root tears (MMPRT) account for 20% or more of all meniscus tears, but the diagnosis and treatment of this condition continues to plague the general population due to the complexity of the diagnosis and uncertainty of the treatment. Early as well as timely diagnosis and treatment is one of the effective ways to avoid accelerated knee degeneration. Based on this study, our team is going to conduct a clinical study on posterior medial meniscus tear, combining Magnetic Resonance Imaging(MRI) to dynamically assess the changes of meniscus and articular cartilage surface after the injury, and selecting a specific patient group to carry out different therapeutic interventions, which mainly include conservative treatment, partial meniscectomy, and meniscal repair, in order to clarify the effects of different treatment modalities on the articular cartilage after the posterior meniscus tear, and to help to delay the degeneration of knee joints. This is to clarify the effects of different treatment modalities on the articular cartilage after posterior medial meniscus tears and to provide appropriate advice for delaying the progression of osteoarthritis of the knee.

Eligibility criteria

This trial does not accept healthy volunteers

Qualifiers

Clinical diagnosis of posterior root tear of the medial meniscus;

Patients with K-L classification ≤ grade II;

The age range of 50-65 years old;

International Cartilage Repair Society (ICRS) Modified Magnetic Resonance Imaging Grading System ≤ Grade 2;

Disqualifiers

Can not participate in this study;

Patients with concomitant meniscal injuries elsewhere;

knee joint infection disease;

Osteoporosis disease;

Trial population

Patients with posterior root injuries of the medial meniscus

Trial design

Design model

Cohort

Time perspective

Prospective

Treatments tested in this trial

  • Arthroscopic meniscus surgery

    Procedure/Surgery

    Comparison of the incidence of osteoarthritis with conservative treatment as well as arthroscopic partial resection as well as arthroscopic repair surgery for a condition known as posterior meniscus root injury.

Treatment groups

69 Participants
are divided into 3 treatment groups
Group A: Conservative treatment group0 interventions
Group B: Arthroscopic partial meniscectomy group1 intervention
Group C: Arthroscopic meniscus suture repair group1 intervention

Trial outcomes

Primary outcomes

1

the incidence of KOA

Time frame
30th November 2024 -30th November 2027

Secondary outcomes

1

Articular cartilage T2-mapping value

Articular cartilage T2 mapping values, post-standardised range 0-1

Time frame
30th November 2024 -30th November 2027

Other outcomes

1

VAS (visual analogue scale),VAS score

The specific scoring method is to draw a 10 cm horizontal line on top of the paper, with 0 at one end of the line indicating no pain, 10 at the other end indicating severe pain, and the middle portion indicating varying degrees of pain.

Time frame
30th November 2024 -30th November 2027
2

Lysholm score

The score consists of eight indicators: pain (25 points), instability (25 points), atresia (15 points), swelling (10 points), limp (5 points), stair climbing (10 points), squatting posture (5 points), and the use of supports (5 points), with a total score of 100, with higher scores representing better knee function. 95 points or more is considered excellent, 94-85 points is good, 84-65 points is fair, and less than 65 points is poor. A score of less than 65 is poor.

Time frame
30th November 2024 -30th November 2027
3

HSS (Hospital for Special Surgery) Score

The score is out of 100 and consists of pain (30 points), function (22 points including walking and stair climbing), knee mobility (18 points), muscle strength (10 points), flexion deformity (10 points), joint stability (10 points), and deductions (-5 points). The higher the score, the better the knee function.

Time frame
30th November 2024 -30th November 2027

Locations

This trial has no locations.

Sponsors and contacts

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