A Study to Test the Diagnostic Potential of Brillouin Microscopy for Corneal Ectasia
Trial statusRecruiting
Trial phaseNot listed
Trial typeObservational
Biological sexAll
Age20-75
SponsorMassachusetts General Hospital
About this trial
We have developed novel Brillouin microscopy and we are testing its potential for keratoconus and ectasia diagnostics. We plan to perform axial scans of the cornea in human volunteers in order to compare biomechanical properties of Keratoconus vs. Normal corneas and compare biomechanical properties of post-LASIK ectasia vs. normal corneas.
Eligibility criteria
This trial accepts healthy volunteersQualifiers
None
Disqualifiers
Have occludable narrow angles (without a patent peripheral iridotomy)
Monocular subjects
Do not or cannot understand the instructions for the imaging
Trial population
General population
Trial design
Design model
Cohort
Time perspective
Cross-sectional
Treatments tested in this trial
Brillouin imaging
Procedure/Surgery
Treatment groups
168 Participants
are divided into 7 treatment groups7
Treatment groupsSee each treatment group below.
Group A: Healthy volunteers1 intervention
Group B: Patients with keratoconus1 intervention
Group C: post-LASIK no complications1 intervention
Group D: post-LASIK who developed ectasia1 intervention
Group E: Volunteers to receive PRK surgery1 intervention
Group F: Volunteers to receive LASIK Surgery1 intervention
Group G: Patients with Fuch's Endothelial Corneal Dystrophy1 intervention
Trial outcomes
Primary outcomes
1
Elastic Modulus of the Cornea
Patients will be measured one time only at their imaging session
Time frame
2012-2022Sponsors and contacts
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Massachusetts General Hospital
Lead sponsor
Harvard Medical School (HMS and HSDM)
Collaborator
Source ClinicalTrials.gov