The main purpose of this study is to increase the pool of organs available for donation by performing ARP to recondition donation after cardiac death (DCD) organs prior to transplantation. We will compare the outcomes of our ARP DCD liver transplants with historical data to determine the efficacy of this treatment compared to transplantation with standard DCD and donation after brain death (DBD) organs. We will also analyze biological samples from donors and recipients and compare them with outcome data in an effort to determine if any biological markers are able to predict the quality/success of the grafts.
Indications for Liver transplant include decompensated Cirrhosis of any etiology Model for End-Stage Liver Disease (MELD) score > 15 with no contraindications to liver transplant as per conventional clinical practice.
Inadequate social support for liver transplant
Non-compliance with alcohol or narcotic cessation
Evidence of uncontrolled infection
Other untreated malignancy aside from those listed above
Single group
Abdominal Regional Perfusion
DeviceAbdominal Regional Perfusion
Primary non-function
Graft failure requiring re-transplantion
Early allograft dysfunction
Transient non-functioning of the liver transplant but with usual recovery to full functioning liver
Ischemic Cholangiopathy
Non-anastomotic biliary stricture without other identifiable etiology
Overall patient survival
Patient Mortality at any time post transplant
Graft survival
Need for retransplant secondary to graft failure of any cause, or death
Biliary anastomotic stricture
Imaging or biochemical evidence of anastomotic stricture requiring intervention
Biliary Anastomotic leak
Imaging or endoscopic evidence of bile leak requiring antibiotics or percutaneous drainage
Length of ICU stay
Duration of post-operative stay in ICU
Overall Length of stay
Overall duration of stay in hospital post-transplant
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