Health TrialsbyHealthPanel

Ablation of Consecutive Atrial Tachycardia

ConditionsHeart ArrhythmiaHeart DiseasesArrhythmias, CardiacAtrial Tachycardia
Trial statusRecruiting
Trial phaseNot applicable
Trial typeInterventional
Biological sexAll
Age18+
SponsorEvangelical Hospital Düsseldorf

About this trial

Ablation of consecutive atrial tachycardia (AT) after ablation of atrial fibrillation (AF) or cardiac surgery can be challenging due to complex substrate and AT mechanisms. A substantial portion of patients is known to show various tachycardias and recurrences occur in a noticeable number of cases. With the availability of novel ultra-high-density mapping techniques characterization and understanding of AT mechanisms and underlying substrate can be improved. Aim of this prospective, multi-center, randomized study is to compare a standard AT ablation approach versus minimalized ablation of the clinical AT in regards to arrhythmia free survival.

Eligibility criteria

This trial does not accept healthy volunteers

Qualifiers

Consecutive AT subsequent to prior AF ablation procedure or cardiac surgery

Surface ECG-documentation of AT as primary clinical arrhythmia

ECG indicating stable, map-able AT (stable activation sequence, and CL stability) with cycle length ≥ 200ms

Disqualifiers

< 18 years

No previous atrial fibrillation ablation procedure or cardiac surgery

Pregnant women or women of childbearing potential without a negative pregnancy test within 48 hours prior to treatment

History of hemorrhagic diathesis or other coagulopathies

Trial design

Design model

Parallel

Treatments tested in this trial

  • Catheter ablation

    Procedure/Surgery

    Catheter-based ablation of arrhythmias using radiofrequency.

Treatment groups

100 Participants
are divided into 2 treatment groups
Group A: Standard approachExperimental treatment 1 intervention
Group B: Minimalized approachExperimental treatment 1 intervention

Trial outcomes

Primary outcomes

1

Recurrence of any sustained arrhythmia (>30 sec.)

Time frame
1 year

Secondary outcomes

1

Inducibility of atrial tachycardia (AT) after ablation of clinical/primary AT (partial success)

Categorical variable (yes/no)

Time frame
Intraprocedural
2

Predictability of secondary AT by analysis of clinical AT map and voltage map

Time frame
Intraprocedural
3

Procedure duration time

Time frame
Intraprocedural
4

Fluoroscopy time

Time frame
intraprocedural

Other outcomes

Sponsors and contacts

Click on the lead sponsor to view all of their trials.

Evangelical Hospital Düsseldorf

Lead sponsor

Source ClinicalTrials.gov
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