The aim of this study is to analyze the association between a deformity of the cranial portion of the central spinal canal and syringomyelia in patients with a Chiari-type malformation of the craniocervical junction.
The investigators hypothesize that Chiari malformation, defined by the herniation of the cerebellar tonsils through the foramen magnum, may be responsible for a deformation of the cranial portion of the central spinal canal, and that this deformation is associated with the presence of syringomyelia in patients with this malformation.
Adult patients being treated for Chiari malformation or syringomyelia at Bordeaux University Hospital
Patients admitted for an initial surgical consultation regarding Chiari malformation with or without syringomyelia at Bordeaux University Hospital
Individuals enrolled in or covered by a social security program.
Free, informed, and express consent (confirmed in writing) (no later than the day of enrollment and prior to any examination required by the study).
Pregnant or breastfeeding patients
Contraindications to MRI
Individuals deprived of their liberty by judicial or administrative order,
Adults subject to legal protective measures (guardianship, conservatorship, judicial protection).
Parallel
MRI
Procedure/SurgeryMagnetic Resonance Imaging (MRI) using T1, T2, White-Matter nulled (WMn), and diffusion sequences
Deformation of the central canal of the spinal cord
The central canal deformation index of the spinal cord, calculated based on the angle of the curves and the length of each segment between two curves.
Protrusion of the cerebellar tonsils
Protrusion of the cerebellar tonsils into the foramen magnum on T2-weighted MRI. Commonly accepted definition of Chiari malformation Type I: cerebellar tonsils extending more than 5 mm below the McRae line on MRI. The McRae line is defined as the anatomical line connecting the basion and the opisthion, corresponding to the anterior and posterior margins of the foramen magnum.
Presence and dimensions of syringomyelia
The presence and dimensions of syringomyelia on MRI using T2 and WMn-MPRAGE sequences
Distance between the obex and the foramen magnum
Distance between the obex and the foramen magnum on T2-weighted and WMn-MPRAGE MRI sequences
Diffusion MRI parameter (1)
Diffusion MRI parameter (mean diffusivity) in the pericanalicular region
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University Hospital, Bordeaux
Lead sponsor
University of Bordeaux
Collaborator
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