About this trial
The goal of this prospective study is to evaluate the feasibility, sustainability, and public health impact of a district-based program for secondary prevention of Rheumatic Heart Disease (RHD) in Uganda.
Eligibility criteria
This trial does not accept healthy volunteersQualifiers
residing in one of two involved districts in Uganda
providers at HCIIIs and HCIVs located in one of two involved Ugandan districts
Disqualifiers
None
Trial design
Single group
Treatments tested in this trial
ADUNU program for delivery of RHD care services
Other interventionThe ADUNU program will be deployed by the Ugandan Ministry of Health and the involved District Health Offices to include echocardiography integrated into primary healthcare to screen for RHD and a registry-based care system to keep patients linked to care and prophylaxis.
Treatment groups
Trial outcomes
Primary outcomes
Proportion of persons with RHD reached by the ADUNU program
This objective will involve only secondary analysis of de-identified data collected by districts using routine MOH data collection procedures supplemented by some routine program data during the Ministry's rollout of the ADUNU Programme Package. The number of individuals screened and screening positivity rates will be extracted from screening logs implemented and maintained by DHOs and assessed by modality (school fairs, health days, passive health center screening, and active outreach to family members of RHD diagnosed).
Proportion of persons with RHD enrolled in care, retained and adherent to treatment
Secondary analysis of data from the districts RHD registry will be used to assess the proportion of registrants enrolled, retained and adherent to secondary prophylaxis.
Proportion of persons with RHD enrolled in care, retained and adherent to treatment
Secondary analysis of data from the districts RHD registry will be used to assess the proportion of registrants enrolled, retained and adherent to secondary prophylaxis.
Adoption and implementation of the ADUNU program at the organization level surveys
Brief surveys will be filled out by providers who are acting as administrators of their health centre and will include questions on a range of logistic (e.g., availability of commodities and stockouts, basic infrastructure reliability) and organizational readiness topics (e.g., staffing levels and turnover, organization of patient scheduling, district support visits)
Sponsors and contacts
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Children's Hospital Medical Center, Cincinnati
Lead sponsor
Uganda Heart Institute
Collaborator