Accelerating Delivery of rheUmatic Heart Disease Preventive iNterventions in Northern Uganda

Trial statusRecruiting
Trial phaseNot applicable
Trial typeInterventional
Biological sexAll
Age5+
SponsorChildren's Hospital Medical Center, Cincinnati

About this trial

The goal of this prospective study is to evaluate the feasibility, sustainability, and public health impact of a district-based program for secondary prevention of Rheumatic Heart Disease (RHD) in Uganda.

Eligibility criteria

This trial does not accept healthy volunteers

Qualifiers

residing in one of two involved districts in Uganda

providers at HCIIIs and HCIVs located in one of two involved Ugandan districts

Disqualifiers

None

Trial design

Design model

Single group

Treatments tested in this trial

  • ADUNU program for delivery of RHD care services

    Other intervention

    The ADUNU program will be deployed by the Ugandan Ministry of Health and the involved District Health Offices to include echocardiography integrated into primary healthcare to screen for RHD and a registry-based care system to keep patients linked to care and prophylaxis.

Treatment groups

221 Participants
are divided into 1 treatment group
Group A: ADUNU ParticipantsOther 1 intervention

Trial outcomes

Primary outcomes

1

Proportion of persons with RHD reached by the ADUNU program

This objective will involve only secondary analysis of de-identified data collected by districts using routine MOH data collection procedures supplemented by some routine program data during the Ministry's rollout of the ADUNU Programme Package. The number of individuals screened and screening positivity rates will be extracted from screening logs implemented and maintained by DHOs and assessed by modality (school fairs, health days, passive health center screening, and active outreach to family members of RHD diagnosed).

Time frame
5 year endpoint
2

Proportion of persons with RHD enrolled in care, retained and adherent to treatment

Secondary analysis of data from the districts RHD registry will be used to assess the proportion of registrants enrolled, retained and adherent to secondary prophylaxis.

Time frame
3 months
3

Proportion of persons with RHD enrolled in care, retained and adherent to treatment

Secondary analysis of data from the districts RHD registry will be used to assess the proportion of registrants enrolled, retained and adherent to secondary prophylaxis.

Time frame
24 months
4

Adoption and implementation of the ADUNU program at the organization level surveys

Brief surveys will be filled out by providers who are acting as administrators of their health centre and will include questions on a range of logistic (e.g., availability of commodities and stockouts, basic infrastructure reliability) and organizational readiness topics (e.g., staffing levels and turnover, organization of patient scheduling, district support visits)

Time frame
Baseline

Secondary outcomes

Other outcomes

Sponsors and contacts

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