Capsimax is a novel, proprietary encapsulated form of capsaicin, a natural and bioactive phytochemical found in chili pepper and other spicy food. The purpose of this study is to investigate the effect of Capsimax on resistance exercise performance, reaction time, and resting energy expenditure around exercise. This investigation will also measure muscle oxygenation and intramuscular nitric oxide in real time during resistance exercise using a non-invasive wearable technology.
Primary Objective • To examine the effects of Capsimax on physical performance metrics including peak power and rate of force development during an isometric strength test and performance during the barbell back squat exercise protocol (e.g., repetitions performed, total volume, peak power, average power).
Secondary Objectives
* To examine the effects of Capsimax on resting energy expenditure around exercise. * To examine the effects of Capsimax on nitric oxide bioavailability and skeletal muscle oxygenation during exercise.
Exploratory Objective
• To examine the effects of Capsimax on reaction time around exercise
Male subjects aged between 18-35 years (both limits inclusive).
Subjects must have a BMI of 18.5 to 29.9 kg/m2 (both limits inclusive)
Subjects must have greater than one year of resistance training experience at a frequency of 2 days per week.
Subjects must be proficient in the barbell back squat exercise.
Subjects who have hypersensitivity or history of allergy to the study product.
Subjects with inability to swallow soft gel capsules.
Subjects with any other medical condition that might adversely impact the safety of the study participants or confound the study results.
Subjects who require medications.
Crossover
A novel, proprietary encapsulated form of Capsicum extract in beadlet form standardized to 2% capsaicinoids
Dietary supplementThis study will investigate the effect of the supplement on exercise performance.
Resistance exercise performance
Performance during the barbell back squat exercise protocol (e.g., repetitions performed, total volume, peak power, average power).
Isometric strength test
Physical performance metrics will be assessed during an isometric mid-thigh pull test including peak power and rate of force development
Energy expenditure
Resting energy expenditure metrics
Nitric oxide release and skeletal muscle oxygenation
Prior to initiating the barbell back squat exercise protocol, participants will have a sensor (NNOXX One, NNOXX Inc.) secured to a standardized position on the thigh to measure nitric oxide release and muscle oxygenation (i.e., a measure of how much blood and oxygen is being delivered to the working muscle) during exercise. This is a non-invasive device that adheres to the skin with tape and allows for real-time feedback regarding the status of the muscle (Figure 1). NNOXX One utilizes spectrometer and optical sensors to non-invasively measure muscle oxygenation and nitric oxide by analyzing the absorption and reflection of light interacting with bodily tissues.
Subjective feelings of pain and rating of perceived exertion
Questionnaires will be provided prior to supplementation, prior to exercise, and following the resistance exercise protocol. Participants will be instructed to assess their subjective feelings of fatigue and pain using a 15-cm visual analog scale (VAS). The scale will be anchored by the words "low" and "high" to represent extreme ratings where the greater measured value represents a greater feeling. Questions will be structured as "My level of fatigue is." Participants will be asked to rate their feelings at each time point by marking on the corresponding line. A rating of perceived exertion (RPE) will also be recorded following the resistance exercise protocol.
Reaction time
Reaction time will be assessed with a visual-cognitive reactionary test
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Hofstra University
Lead sponsor
OmniActive Health Technologies
Collaborator
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