Acute Effects of Isoenergetic HIIE vs. MICE on Key Parameters of Fat Mass Loss in Young Females With Overweight or Obesity

Trial statusRecruiting
Trial phaseNot applicable
Trial typeInterventional
Biological sexFemale
Age20-45
SponsorLaboratoire des Adaptations Métaboliques à l'Exercice en conditions Physiologiques et Pathologiques

About this trial

Overweight and obesity, particularly increased total and/or abdominal fat mass (FM), are strongly linked to the development of cardiovascular diseases. Managing obesity effectively requires lifestyle and dietary modifications, including increased physical activity. Among the various exercise strategies, Moderate-Intensity Continuous Training (MICT) and High-Intensity Interval Training (HIIT) are widely recommended for reducing FM. Compared to MICT, HIIT is a time-efficient approach, often perceived as more enjoyable, and has been shown to promote greater total and abdominal fat loss in a shorter period. However, the precise mechanisms underlying this enhanced fat loss remain unclear.

This study aims to compare the acute effects of two isoenergetic exercise sessions - MICE (Moderate-Intensity Continuous Exercise) and HIIE (High-Intensity Interval Exercise) - on key physiological responses involved in fat mass loss. Specifically, we will assess plasma catecholamine levels during exercise and recovery, as well as oxygen consumption, substrate oxidation, and appetite over the 2-hour post-exercise period in young females with overweight or obesity. By elucidating the role of catecholaminergic stimulation as a potential regulator of fat mass loss, this research could provide valuable insights for optimizing exercise strategies in weight management and metabolic health.

Eligibility criteria

This trial accepts healthy volunteers

Qualifiers

women with overwieght or obesity (BMI: 25-35 kg/m²)

Disqualifiers

contraceptive use

menopause

irregular menstrual cycle

medical contraindications to intense physical activity,

Trial design

Design model

Crossover

Treatments tested in this trial

  • Exercise

    Other intervention

    Two Exercise Modalities: HIIE and MICE

Treatment groups

15 Participants
are divided into 2 treatment groups
Group A: High Intensity Interval ExerciseExperimental treatment 1 intervention
Group B: Moderate Intensity Continuous ExerciseExperimental treatment 1 intervention

Trial outcomes

Primary outcomes

1

Oxygen consumption during exercise and the recovery period

Determination of oxygen consumption during exercise and 2 hours after the exercise session (HIIE and MICE). Determination from Metamax (3D Cortex).

Time frame
Measurement at rest for 20 minutes, then during warm-up for 10 minutes, then during exercise for 20 minutes and finally during 2 hours after the end of the exercise.

Secondary outcomes

1

Lipid before and after the exercise.

Determination of lipid oxidation before and after the exercise. Lipid oxidation is measured from oxygen and carbon dioxide consumption (Metamax 3D Cortex).

Time frame
Measurement at rest for 20 minutes and then during 2 hours after the end of the exercise.
2

Carbohydrate before and after the exercise.

Determination of carbohydrate oxidation before and after the exercise. Carbohydrate oxidation is measured from oxygen and carbon dioxide consumption (Metamax 3D Cortex).

Time frame
Measurement at rest for 20 minutes and then during 2 hours after the end of the exercise.
3

Catecholamines

Determination of cathecolamines concentration in blood during exercise and 2 hours after the end of the exercise.

Time frame
5 collections: before exercise started, at the end of exercise (exercise duration is 20-35 minutes), at 30 minutes, 60 minutes and 120 minutes after the end of exercise
4

Energy intakes 24 hours after the exercise

Evaluation of energy intakes after the exercise session (HIIE vs MICE). Exercise session finish at 11:30 a.m. After that, at home, participants have to complete by themselves a food-record on which they will describe all their meal during 24 hours after the end of the exercise session. It includes their lunch, dinner and their breakfast the next morning.

Time frame
24 hours post exercise

Other outcomes

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