About this trial
Overweight and obesity, particularly increased total and/or abdominal fat mass (FM), are strongly linked to the development of cardiovascular diseases. Managing obesity effectively requires lifestyle and dietary modifications, including increased physical activity. Among the various exercise strategies, Moderate-Intensity Continuous Training (MICT) and High-Intensity Interval Training (HIIT) are widely recommended for reducing FM. Compared to MICT, HIIT is a time-efficient approach, often perceived as more enjoyable, and has been shown to promote greater total and abdominal fat loss in a shorter period. However, the precise mechanisms underlying this enhanced fat loss remain unclear.
This study aims to compare the acute effects of two isoenergetic exercise sessions - MICE (Moderate-Intensity Continuous Exercise) and HIIE (High-Intensity Interval Exercise) - on key physiological responses involved in fat mass loss. Specifically, we will assess plasma catecholamine levels during exercise and recovery, as well as oxygen consumption, substrate oxidation, and appetite over the 2-hour post-exercise period in young females with overweight or obesity. By elucidating the role of catecholaminergic stimulation as a potential regulator of fat mass loss, this research could provide valuable insights for optimizing exercise strategies in weight management and metabolic health.
Eligibility criteria
This trial accepts healthy volunteersQualifiers
women with overwieght or obesity (BMI: 25-35 kg/m²)
Disqualifiers
contraceptive use
menopause
irregular menstrual cycle
medical contraindications to intense physical activity,
Trial design
Crossover
Treatments tested in this trial
Exercise
Other interventionTwo Exercise Modalities: HIIE and MICE
Treatment groups
Trial outcomes
Primary outcomes
Oxygen consumption during exercise and the recovery period
Determination of oxygen consumption during exercise and 2 hours after the exercise session (HIIE and MICE). Determination from Metamax (3D Cortex).
Secondary outcomes
Lipid before and after the exercise.
Determination of lipid oxidation before and after the exercise. Lipid oxidation is measured from oxygen and carbon dioxide consumption (Metamax 3D Cortex).
Carbohydrate before and after the exercise.
Determination of carbohydrate oxidation before and after the exercise. Carbohydrate oxidation is measured from oxygen and carbon dioxide consumption (Metamax 3D Cortex).
Catecholamines
Determination of cathecolamines concentration in blood during exercise and 2 hours after the end of the exercise.
Energy intakes 24 hours after the exercise
Evaluation of energy intakes after the exercise session (HIIE vs MICE). Exercise session finish at 11:30 a.m. After that, at home, participants have to complete by themselves a food-record on which they will describe all their meal during 24 hours after the end of the exercise session. It includes their lunch, dinner and their breakfast the next morning.
Sponsors and contacts
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Laboratoire des Adaptations Métaboliques à l'Exercice en conditions Physiologiques et Pathologiques
Lead sponsor
Universidade Cidade de Sao Paulo
Collaborator