About this trial
The goal of this clinical trial is to evaluate the effects of medium-chain triglycerides (MCTs), delivered in different formulations, on beta-hydroxybutyrate response (as a marker of ketone body production), lipid metabolism, and glucose responses in healthy adults.
The main questions it aims to answer are:
Do MCTs influence beta-hydroxybutyrate responses, lipid metabolism, and glucose responses differently compared to long-chain triglycerides (LCTs)?
Do different types of MCTs (natural sources containing C8 to C12 versus synthetic formulations containing only C8 and C10) lead to different beta-hydroxybutyrate, lipid, and glucose responses?
Does the form in which MCTs are consumed (e.g., powders or incorporated into foods) influence beta-hydroxybutyrate production, lipid metabolism, and glucose responses?
Researchers will compare five different lipid formulations to evaluate their effects on postprandial beta-hydroxybutyrate concentrations, blood lipid levels, and glucose.
Participants will:
Consume five different test products on separate study visits. Provide blood samples for up to five hours after each intake for metabolic measurements.
Eligibility criteria
Qualifiers
Healthy adult participants
Age between 18 and 40 years
Ability to understand the study procedures and provide informed consent
Disqualifiers
Alterations in glucose or lipid metabolism
Diseases requiring the use of medications that affect glucose or lipid metabolism
Reported or diagnosed malabsorption conditions
Pregnancy or breastfeeding
Trial design
Treatments tested in this trial
- MCT Beverage
- LCT Beverage
- Synthetic MCT Powder
- Natural MCT Powder
- MCT Biscuit
Treatment groups
Sponsors and collaborators
University of Milan
Lead sponsor
University of Florence
Collaborator