Acute Effects of MCT Formulations on Beta-Hydroxybutyrate Response, Lipid Profile, and Glucose Levels in Healthy Adults

Trial statusRecruiting
Trial phaseNot applicable
Trial typeInterventional
Biological sexAll
Age18-40
SponsorUniversity of Milan

About this trial

The goal of this clinical trial is to evaluate the effects of medium-chain triglycerides (MCTs), delivered in different formulations, on beta-hydroxybutyrate response (as a marker of ketone body production), lipid metabolism, and glucose responses in healthy adults.

The main questions it aims to answer are:

Do MCTs influence beta-hydroxybutyrate responses, lipid metabolism, and glucose responses differently compared to long-chain triglycerides (LCTs)?

Do different types of MCTs (natural sources containing C8 to C12 versus synthetic formulations containing only C8 and C10) lead to different beta-hydroxybutyrate, lipid, and glucose responses?

Does the form in which MCTs are consumed (e.g., powders or incorporated into foods) influence beta-hydroxybutyrate production, lipid metabolism, and glucose responses?

Researchers will compare five different lipid formulations to evaluate their effects on postprandial beta-hydroxybutyrate concentrations, blood lipid levels, and glucose.

Participants will:

Consume five different test products on separate study visits. Provide blood samples for up to five hours after each intake for metabolic measurements.

Eligibility criteria

Qualifiers

Healthy adult participants

Age between 18 and 40 years

Ability to understand the study procedures and provide informed consent

Disqualifiers

Alterations in glucose or lipid metabolism

Diseases requiring the use of medications that affect glucose or lipid metabolism

Reported or diagnosed malabsorption conditions

Pregnancy or breastfeeding

Trial design

Treatments tested in this trial

  • MCT Beverage
  • LCT Beverage
  • Synthetic MCT Powder
  • Natural MCT Powder
  • MCT Biscuit

Treatment groups

12 Participants
are divided into 1 treatment group

Sponsors and collaborators

University of Milan

Lead sponsor

University of Florence

Collaborator