Acute Effects of Meteorological Factors and Air Pollution on Cardiovascular Health
Trial statusRecruiting
Trial phaseNot listed
Trial typeObservational
Biological sexAll
Age18-75
SponsorThe Affiliated Hospital of Hangzhou Normal University
About this trial
The goal of this observational study is to analyze the acute effects of meteorological factors and air pollution on cardiovascular system. The main question it aims to answer is:
1. How do meteorological factors and air pollution affect cardiovascular system? 2. What is the interaction between meteorological factors and air pollution on cardiovascular system?
Participants will:
1. Provide their health data obtained in physical examination, including but not limited to blood pressure, blood routine, urine routine and B-ultrasound. 2. agree that the research team will use their personal identification number, gender, age, education level and other information for statistical analysis of the data.
Eligibility criteria
This trial accepts healthy volunteersQualifiers
None
Disqualifiers
Relevant records in the physical examination database shall be ≥３times
Serious heart and lung diseases
Malignant tumors
Serious mental illness in the past
Trial population
1. Target population: adults who have been recorded at least three times in the physical examination database will be included in this study. This requirement aims to ensure that the participants\' health status can be fully evaluated historically, and then to study the changes of various health indicators over time. 2. Sample source and recruitment: Participants will be selected from the routine physical examination database of several hospital physical examination centers in Zhejiang, Henan, Anhui, Guizhou and other provinces.
Trial design
Design model
Cohort
Time perspective
Retrospective
Treatments tested in this trial
NOT
Other interventionThis retrospective cohort study involves no new interventions. It analyzes existing health data collected from subjects exposed to varying atmospheric conditions to assess impacts on health outcomes.
Treatment groups
350,000 Participants
are divided into 4 treatment groupsGroup A: High Temperature Group1 intervention
Group B: Low Temperature Group1 intervention
Group C: High Pollution Group1 intervention
Group D: Low Pollution Group1 intervention
Trial outcomes
Primary outcomes
1
Troponin
Troponin data were obtained by blood biochemical detection data recorded in the diagnosis and treatment system, with unit of µg/L.
Time frame
The troponin data were tested at baseline 3 months before exposure tometeorological factors or air pollution, and followed up for 1 year and 2 years after exposure.2
Blood pressure
Blood pressure data were obtained from the diagnosis and treatment record system and analyzed by standard sphygmomanometer, with unit of mmHg.
Time frame
The blood pressure data were tested at baseline 3 months before exposure tometeorological factors or air pollution, and followed up for 1 year and 2 years after exposure.Secondary outcomes
1
Left ventricular ejection fraction（LVEF）
Left ventricular ejection fraction（LVEF）data were obtained by Cardiac color ultrasound data recorded in the diagnosis and treatment system, with unit of %
Time frame
The left ventricular ejection fraction（LVEF）data were tested at baseline 3 months before exposure tometeorological factors or air pollution, and followed up for 1 year and 2 years after exposure.2
White cell count
White cell count data were obtained by blood routine blood data recorded in the diagnosis and treatment system, with unit of 10\^9/L
Time frame
The white cell count data were tested at baseline 3 months before exposure to meteorological factors or air pollution, and followed up for 1 year and 2 years after exposure.3
Controlled Attenuation Parameter（CAP）
Controlled Attenuation Parameter（CAP）data were obtained by Diagnosis of hepatic fibrosis data recorded in the diagnosis and treatment system, with unit of dB/m.
Time frame
The Controlled Attenuation Parameter（CAP）data were tested at baseline 3 months before exposure tometeorological factors or air pollution, and followed up for 1 year and 2 years after exposure.4
ST segment of electrocardiogram
ST segment were obtained by Electrocardiogram (ECG) recorded in the diagnosis and treatment system with unit of mV.
Time frame
The ST segment of electrocardiogram were tested at baseline 3 months before exposure tometeorological factors or air pollution, and followed up for 1 year and 2 years after exposure.Locations
1Map coordinates are unavailable for these locations. Locations are shown below instead.
MingWei WangRecruiting310000, Hanzhou, Zhejiang
China
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Source ClinicalTrials.gov