The overall aim of this study is to investigate the effects of exercise on the amount of glucose that is made by the liver in people with and without Type 2 diabetes (T2D) and hepatic steatosis (fatty liver).
Provision of signed and dated informed consent form
Stated willingness to comply with all study procedures and availability for the duration of the study
Male or (pre-menopausal) female, aged 25-55 years
Body mass index (BMI) between 25 and 45 kg/m2
Exclusion criteria for individuals with T2D and elevated liver fat ≥5.6% Currently taking insulin, incretin mimetics, and/or thiazolidinediones
Any change in glucose-lowering medications within the previous three months.
Inability to stop any medications which interfere with glucose metabolism for visits 4 and 7.
Resting blood pressure ≥ 160/100 mm Hg
Parallel
Magnetic Resonance Liver Assessment
Other interventionLiver fat will be measured by MR imaging to assess level of hepatic steatosis.
Bike Exercise VO2max
Other interventionMaximal fitness measured by cycle ergometer.
DEXA
Other interventionMeasure body composition (fat and lean body mass).
Measurement of Endogenous Glucose Production (EGP)
Bulk EGP will be measured during resting and exercise conditions to determine how Endogenous Glucose Production (EGP) differs during exercise (compared to no exercise) in T2D and Metabolic dysfunction associated steatotic liver disease (MASLD).
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