Acute Mental Fatigue and Muscle Strength
Trial statusRecruiting
Trial phaseNot applicable
Trial typeInterventional
Biological sexAll
Age18-39
SponsorFlorida Institute for Human and Machine Cognition
About this trial
This study will investigate the acute effects of mental fatigue on lower-extremity muscle strength and limb symmetry in healthy young adults. Participants will complete lower-extremity strength testing before and after a standardized computer-based mental fatigue protocol involving tasks of attention, reaction time, concentration, and working memory. Muscle strength and limb symmetry will be assessed using isokinetic dynamometry, with muscle activity measured using surface electromyography. Participants will also complete subjective measures of mental fatigue, sleepiness, mental effort, and perceived physical exertion. Heart rate will be monitored throughout the study, and brain activity may be assessed during cognitive tasks. The study will determine whether acute mental fatigue is associated with changes in muscle strength, limb symmetry, and neuromuscular performance.
Eligibility criteria
This trial accepts healthy volunteersQualifiers
Age 18-39 years
Able to produce maximal force against Biodex protocol
Able to perform required lower extremity movements through range of motion necessary for Biodex protocol
No known cognitive impairment
Disqualifiers
History of a neurological disorder, disease, or cognitive impairment that may affect cognition, motor control, reaction time, or force production
History of musculoskeletal injury affecting the lower extremities within the past 6 months
History of lower extremity surgery affecting force production of the hip, knee, or ankle
Color-vision impairment
Trial design
Design model
Single group
Treatments tested in this trial
Computer-Based Mental Fatigue Protocol
Other interventionParticipants will complete approximately 30 minutes of standardized computer-based cognitive tasks designed to induce acute mental fatigue. The tasks require sustained attention, concentration, reaction time, working memory, and mental effort and may include the Psychomotor Vigilance Task (PVT), incongruent Stroop task, and n-back task. Participants will complete the mental fatigue protocol after baseline strength testing and before the post-intervention strength assessment. Subjective mental fatigue and sleepiness will be assessed before and after the intervention, and perceived mental effort will be assessed following the intervention.
Treatment groups
50 Participants
are divided into 1 treatment groupGroup A: Mental Fatigue InterventionExperimental treatment 1 intervention
Trial outcomes
Primary outcomes
1
Lower-Extremity Muscle Strength
Lower-extremity muscle strength will be assessed using a Biodex isokinetic dynamometer during bilateral knee extension and flexion at three different movement speeds. Peak torque will be recorded as the primary measure of muscle strength. Changes in peak torque from baseline to immediately following the computer-based mental fatigue intervention will be evaluated.
Time frame
Baseline and immediately following the approximately 30-minute mental fatigue intervention, during a single study visit lasting up to 2 hours.2
Lower-Extremity Limb Symmetry
Limb symmetry will be assessed using peak torque measurements obtained from both lower extremities during isokinetic knee extension and flexion testing. A Limb Symmetry Index (LSI) will be calculated to quantify the similarity in muscle strength between the two lower extremities. Changes in LSI from baseline to immediately following the computer-based mental fatigue intervention will be evaluated.
Time frame
Baseline and immediately following the approximately 30-minute mental fatigue intervention, during a single study visit lasting up to 2 hours.Sponsors and contacts
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Source ClinicalTrials.gov