Acute Treatment and Long-term Assessment of Adult Infectious Meningitis
Trial statusRecruiting
Trial phaseNot listed
Trial typeObservational
Biological sexAll
Age18+
SponsorHospital Israelita Albert Einstein
About this trial
Prospective, multicenter, observational clinical registry of adult patients with acute infectious meningitis across approximately 30 public and private hospitals in Brazil. The study will include adults, 18 years old and older, with suspected acute infectious meningitis. Data will be collected during hospitalization and post-discharge to evaluate clinical management, treatment and short and long-term outcomes. The study aims to generate real-world evidence on current practices and outcomes to support improvements in national care protocols.
Eligibility criteria
This trial does not accept healthy volunteersQualifiers
Severe headache
Vomiting
Altered level of consciousness (confusion, drowsiness, irritability)
Photophobia
Disqualifiers
Refusal to provide consent for the study.
Presence of a neurological condition, other than meningitis, that accounts for the current clinical picture.
Clinical, laboratory or radiological evidence of an alternative infectious focus that accounts for the current clinical picture.
Use of an intraventricular device prior to study inclusion.
Trial population
Adult, ≥ 18 years old, suspect acute meningitis infection
Trial design
Design model
Cohort
Time perspective
Prospective
Treatments tested in this trial
Not listed
Trial groups
No trial groups listed
Trial outcomes
Primary outcomes
1
Mortality
The primary outcome is the incidence of all-cause death
Time frame
Day 28Secondary outcomes
1
Re-hospitalization
Incidence of all-cause re-hospitalization
Time frame
Day 282
Length of hospital stay
Length of initial hospital stay (measured in days)
Time frame
Day 283
Invasive ventilatory support
Incidence of invasive ventilatory support
Time frame
Day 284
Adverse Events
Incidence of adverse events
Time frame
Day 28Sponsors and contacts
Click on the lead sponsor to view all of their trials.
Hospital Israelita Albert Einstein
Lead sponsor
Ministry of Health, Brazil
Collaborator
Source ClinicalTrials.gov