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Adapted Cardiopulmonary Resuscitation Study

ConditionCardiac Arrest (CA)
Trial statusRecruiting
Trial phaseNot applicable
Trial typeInterventional
Biological sexAll
Age18+
SponsorJohannes Kepler University of Linz

About this trial

The goal of this controlled single centre RCT is to compare frequency rates concerning return of spontaneous circulation (ROSC) in prehospital cardiac arrest. Two different algorithms (control-and interventiongroup) of advanced cardiac life support will be used to treat patients. In patients over 18 years suffering from cardiac arrest. The main question aims to answer if the frequency of ROSC differs between the groups receiving either the new Advanced Life Support (ALS) algorithm, or standard treatment.

Researchers will compare the new algorithm to the standard care algorithm to see if there is a difference .

Participants will be randomized to treatment on scene. The controlgroup will receive ALS standard treatment as performed in local protocols.

The intervention group will receive a modified treatment including:

* thorax compression via mechanical device (LUCAS 3) * head up Cardiopulmonary Resuscitation (cpr) * use of an impendance threshold device (ITD) module * arterial line placement * continuous epinephrin infusion via infusion pump * double sequence defibrillation

Eligibility criteria

This trial does not accept healthy volunteers

Qualifiers

Age> 18 years

time of resuscitation <21 minutes when enrollement starts

Disqualifiers

obvious pregnancy

contraindications for the use of Lucas 3

time of resuscitation >21 minutes and etCO2 <15 mmHg upon arrival of the emergency physician on scene

Exclusion from the emergency physician from study due to futility.

Trial design

Design model

Parallel

Treatments tested in this trial

  • aCPR algorithm

    Procedure/Surgery

    * thorax compression via mechanical device (LUCAS 3) * head up cpr * use of an ITD module * arterial line placement * continuous epinephrin infusion via infusion pump * double sequence defibrillation

  • ERC ALS 2025

    Procedure/Surgery

    Placement of an IV line, placement of a supraglottic airway device or endotracheal intubation. Optional use of an intraosseus acces

Treatment groups

216 Participants
are divided into 2 treatment groups
Group A: ALS ERC 2025Active comparator 1 intervention
Group B: adapted CPR algorithmExperimental treatment 1 intervention

Trial outcomes

Primary outcomes

1

ROSC

frequency of ROSC in the study cohort

Time frame
one minute

Secondary outcomes

1

Time to ROSC

comparison between the groups if ROSC can be achieved faster in one group

Time frame
Periprocedural: from enrollement to ROSC or Termination of Resuscitation (TOR)
2

CO2

Measurement of CO2 differences between study arms

Time frame
Periprocedural: from enrollement to ROSC orTOR
3

descriptive data

analyzing vital parameters measured

Time frame
Periprocedural: during study intervention

Other outcomes

Sponsors and contacts

Click on the lead sponsor to view all of their trials.

Johannes Kepler University of Linz

Lead sponsor

Red Cross Upper Austria

Collaborator

Kepler University Hospital

Collaborator

Source ClinicalTrials.gov
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