Additional left atrial appendage isolation during balloon ablation for persistent or long-standing persistent atrial fibrillation can reduce atrial fibrillation reoccurrence within 3-12 months compared to balloon-based pulmonary vein isolation only.
Persistent or long-standing persistent AF (i.e. continuous AF that was/is sustained >7 days or >12 months, respectively)
Age ≥18 and ≤80 years
Indication for AF ablation as per current guidelines
Missing informed consent
LAA diameter >25mm 10mm distant from circumflex artery assessed by TEE
Paroxysmal atrial fibrillation
Long-standing persistent atrial fibrillation with a continuous AF duration of >4 years
Parallel
Control intervention
Procedure/Surgerypatients treated with balloon-based ablation of AF by PVI
Experimental intervention
Procedure/Surgerypatients treated with balloon-based ablation of AF by PVI
Time until any documented episode of ATa
Time until any documented episode of atrial tachyarrhythmia (ATa: atrial fibrillation or atrial tachycardia) lasting longer than 30 seconds within 3-12 months after index ablation without antiarrhythmic therapy
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University of Luebeck
Lead sponsor
IHF GmbH - Institut für Herzinfarktforschung
Collaborator
