Adequacy of Haemodiafiltration: Middle Molecules Clearance, Patients Reported Outcomes and Sodium Balance

ConditionsHaemodiafiltration Haemodialysis Patient Reported Outcome Measurements Nutrition Malnutrition (Calorie)Fluid Balance Outcomes

Trial statusRecruiting

Trial phaseNot listed

Trial typeObservational

Biological sexAll

Age18+

SponsorEast and North Hertfordshire NHS Trust

About this trial

The goal of this observational study is to understand the differences in terms of middle molecules clearance and patient outcomes in High (\>23Litres (L)) vs Low (\<23 L) convection volume (CV) Hemodiafiltration (HDF) and to understand the effect of dialysate fluid sodium concentration (137 vs 140 mmol/L) on overhydration volume in patients on HD and HDF.

Eligibility criteria

Qualifiers

Age 18 years or above.

Ability to give informed consent.

End stage kidney disease (ESKD) treated by haemodialysis for at least 3 months.

Prognosis > 6 months as assessed by principal investigator (PI)

Disqualifiers

None

Trial design

Treatments tested in this trial

Not listed

Trial groups

300 Participants

are grouped into 4 trial groups

Sponsors and collaborators

East and North Hertfordshire NHS Trust

Lead sponsor

Source ClinicalTrials.gov