Adjunctive Effect of Erythritol on Pocket Closure Rates
Trial statusRecruiting
Trial phaseNot applicable
Trial typeInterventional
Biological sexAll
Age35+
SponsorUniversity of L'Aquila
About this trial
This clinical trial is studying whether using erythritol powder during non-surgical periodontal treatment (deep cleaning) helps improve gum health in people with severe periodontitis. Participants with deep gum pockets (4 mm or more) receive standard treatment alone or standard treatment plus cleaning with erythritol powder. The goal is to evaluate if adding erythritol improves outcomes such as healing of gum pockets, bleeding, plaque levels, and gum attachment compared to standard treatment alone.
Eligibility criteria
This trial does not accept healthy volunteersQualifiers
None
Disqualifiers
None
Trial design
Design model
Parallel
Treatments tested in this trial
Non-surgical periodontal therapy + sub-gingival air polishing
Procedure/SurgeryParticipants receive a single session of non-surgical periodontal therapy (NSPT) using ultrasonic and manual instruments, combined with sub-gingival air polishing using erythritol powder. The treatment is applied to periodontal pockets with probing depth ≥ 4 mm in non-adjacent teeth.
Non-surgical periodontal therapy alone
Procedure/SurgeryParticipants receive a single session of non-surgical periodontal therapy (NSPT) using ultrasonic and manual instruments.
Treatment groups
56 Participants
are divided into 2 treatment groupsGroup A: NSPT (Control)Active comparator 1 intervention
Group B: NSPT + ERY (Test)Experimental treatment 1 intervention
Trial outcomes
Primary outcomes
1
Proportion of periodontal pockets with successful pocket closure
Percentage of treated periodontal pockets (with baseline probing depth ≥ 4 mm) that reach pocket closure, defined as probing pocket depth ≤ 4 mm without bleeding on probing, or ≤ 3 mm, at follow-up.
Time frame
2 months and 4 months after treatmentSponsors and contacts
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Source ClinicalTrials.gov